Synthesis and Cytotoxic Activity of Pentacyclic Triterpenoid Sulfamates

Sommerwerk Sven; Heller Lucie; Csuk Rene

首页> 外文期刊>Archiv der Pharmazie >Synthesis and Cytotoxic Activity of Pentacyclic Triterpenoid Sulfamates

【24h】

Synthesis and Cytotoxic Activity of Pentacyclic Triterpenoid Sulfamates

机译：五环三萜磺酸酯的合成及细胞毒活性

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Methyl triterpenoates derived from oleanolic, ursolic, betulinic, glycyrrhetinic, platanic, or maslinic acid were converted into their corresponding sulfamates and carbamoylsulfamates. The sulfamates were screened in photometric sulforhodamine assays for cytotoxic activity employing several human tumor cell lines. Many of the compounds showed EC50 values in one-digit mu M concentration. Of special interest seems methyl (3 beta) 3-(aminosulfonyloxy)-11-oxo-oleanoate (18) showing good cytotoxicity for the human adenocarcinomic alveolar basal epithelial cell line A549 while being less toxic for non-malignant NIH 3T3 mouse fibroblasts.

机译：衍生自齐墩果酸，熊果酸，桦木酸，甘草次酸，铂酸或山梨酸的三萜烯酸甲酯被转化为其相应的氨基磺酸盐和氨基甲酰基氨基磺酸盐。使用几种人类肿瘤细胞系，在光度磺基罗丹明分析中筛选了氨基磺酸盐的细胞毒性活性。许多化合物的EC50值均以一位M浓度表示。特别令人感兴趣的似乎是（3 beta）3-（氨基磺酰氧基）-11-氧-油酸甲酯（18）对人腺癌的肺泡基底细胞上皮细胞系A549显示良好的细胞毒性，而对非恶性NIH 3T3小鼠成纤维细胞的毒性较小。

著录项

来源
《Archiv der Pharmazie》 |2015年第1期|共9页
作者
Sommerwerk Sven; Heller Lucie; Csuk Rene;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 ger
中图分类药学;
关键词
Carbamoylsulfamates; Cytotoxic activity; Triterpenoids; Sulfamates;

机译：氨基甲酸酯氨基磺酸盐;细胞毒活性;三萜;氨基磺酸盐;

相似文献

外文文献
中文文献
专利

1. Synthesis and Cytotoxic Activity of Pentacyclic Triterpenoid Sulfamates [J] . Sommerwerk Sven, Heller Lucie, Csuk Rene Archiv der Pharmazie . 2015,第1期

机译：五环三萜磺酸酯的合成及细胞毒活性
2. Antiplasmodial,cytotoxic activities and characterization of a new naturally occurring quinone methide pentacyclic triterpenoid derivative isolated from Salacia leptoclada Tul.(Celastraceae)originated from Madagascar [J] . Fatiany Pierre Ruphin, Robijaona Baholy, Randrianarivo Emmanuel, 亚太热带生物医学杂志：英文版 . 2013,第010期

机译：从马达加斯加起源的鳞翅目（Salacia leptoclada Tul。（Celastraceae））分离的一种新的天然存在的甲基苯醌甲基化物五环三萜类化合物的抗血浆，细胞毒活性和表征
3. Antiplasmodial, cytotoxic activities and characterization of a new naturally occurring quinone methide pentacyclic triterpenoid derivative isolated from Salacia leptoclada Tul. (Celastraceae) originated from Madagascar [J] . Fatiany Pierre Ruphin, Robijaona Baholy, Randrianarivo Emmanuel, 亚太热带生物医学杂志（英文版） . 2013,第010期

机译：分离自Salacia leptoclada Tul的一种新的天然存在的甲基苯醌甲基化物五环三萜衍生物的抗血浆，细胞毒活性和特征。（Celastraceae）起源于马达加斯加
4. Advances in the synthesis and pharmacological activity of lupane-type triterpenoid saponins [C] . Charles Gauthier, Jean Legault, Marianne Piochon-Gauthier Phytochemical Society of Europe Meeting . 2011

机译：Lupane型三萜皂苷的合成和药理活性进展
5. Synthesis, conformational analysis and cytotoxic activity of friedelane triterpenoids. [D] . Ruan, Xiaoli. 2003

机译：替丁烷三萜类化合物的合成，构象分析和细胞毒活性。
6. Antiplasmodial cytotoxic activities and characterization of a new naturally occurring quinone methide pentacyclic triterpenoid derivative isolated from Salacia leptoclada Tul. (Celastraceae) originated from Madagascar [O] . Fatiany Pierre Ruphin, Robijaona Baholy, Andrianarivo Emmanue, 2013

机译：分离自Salacia leptoclada Tul的一种新的天然存在的甲基醌五环五萜类三萜衍生物的抗血浆细胞毒活性和表征。（Celastraceae）起源于马达加斯加
7. Approaches to the synthesis of triterpenoids: IV: the ABC+E ring approach to the pentacyclic triterpene skeleton. Synthesis of a pentacyclic compound suitable for triterpene synthesis [O] . ApSimon, J. S., Badripersaud, S., Hooper, J. S., 1978

机译：三萜类化合物的合成方法：IV：五环三萜骨架的ABC + E环方法。适用于三萜烯合成的五环化合物的合成

Synthesis and Cytotoxic Activity of Pentacyclic Triterpenoid Sulfamates

摘要

著录项

相似文献

相关主题

期刊订阅