...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta crystallographica. Section D, Structural biology >Structural biology of coronavirus ion channels
【24h】

Structural biology of coronavirus ion channels

机译：冠状病毒离子通道的结构生物学

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Viral infection compromises specific organelles of the cell and readdresses its functional resources to satisfy the needs of the invading body. Around 70% of the coronavirus positive-sense single-stranded RNA encodes proteins involved in replication, and these viruses essentially take over the biosynthetic and transport mechanisms to ensure the efficient replication of their genome and trafficking of their virions. Some coronaviruses encode genes for ion-channel proteins - the envelope protein E (orf4a), orf3a and orf8 - which they successfully employ to take control of the endoplasmic reticulum-Golgi complex intermediate compartment or ERGIC. The E protein, which is one of the four structural proteins of SARS-CoV-2 and other coronaviruses, assembles its transmembrane protomers into homopentameric channels with mild cationic selectivity. Orf3a forms homodimers and homotetramers. Both carry a PDZ-binding domain, lending them the versatility to interact with more than 400 target proteins in infected host cells. Orf8 is a very short 29-amino-acid single-passage transmembrane peptide that forms cation-selective channels when assembled in lipid bilayers. This review addresses the contribution of biophysical and structural biology approaches that unravel different facets of coronavirus ion channels, their effects on the cellular machinery of infected cells and some structure-functional correlations with ion channels of higher organisms.
机译：病毒感染妥协的特定细胞器细胞和再次重述了其功能性资源满足入侵身体的需要。70%的冠状病毒的积极意义单链RNA编码的蛋白质参与这些病毒复制和本质在生物合成和运输机制确保有效的基因组复制和贩卖他们的病毒粒子。冠状病毒基因编码离子通道蛋白质——包膜蛋白E (orf4a) orf3a和orf8——他们成功地采用内质reticulum-Golgi的控制权复杂的中间室或ERGIC。蛋白质,这是四个结构之一蛋白质SARS-CoV-2和其他冠状病毒,组装其跨膜原体homopentameric渠道与温和的阳离子选择性。homotetramers。贷款他们相互作用的多功能性400多目标蛋白在感染宿主细胞。单通道跨膜肽形式当聚集在脂质cation-selective渠道影响。生物物理与结构生物学方法解开不同方面的冠状病毒渠道,他们对细胞机制的影响受感染的细胞和一些structure-functional相关性高的离子通道生物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号