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首页> 外文期刊>Acta crystallographica. Section D, Structural biology. >Membrane-protein crystals for neutron diffraction
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Membrane-protein crystals for neutron diffraction

机译：中子衍射的膜蛋白晶体

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摘要

Neutron macromolecular crystallography (NMX) has the potential to provide the experimental input to address unresolved aspects of transport mechanisms and protonation in membrane proteins. However, despite this clear scientific motivation, the practical challenges of obtaining crystals that are large enough to make NMX feasible have so far been prohibitive. Here, the potential impact on feasibility of a more powerful neutron source is reviewed and a strategy for obtaining larger crystals is formulated, exemplified by the calcium-transporting ATPase SERCA1. The challenges encountered at the various steps in the process from crystal nucleation and growth to crystal mounting are explored, and it is demonstrated that NMX-compatible membrane-protein crystals can indeed be obtained.
机译：中子大分子晶体学(NMX)可能提供实验的输入运输的解决未解决的方面机制和质子化作用在膜蛋白。然而,尽管这个明确的科学动机、获得的实际挑战大到足以让NMX晶体迄今为止,可行的被禁止的。潜在影响的可行性强大的中子源和审查策略获得较大的晶体制定,例证calcium-transporting腺苷三磷酸酶SERCA1。各个步骤的遇到的挑战从晶体成核和生长过程晶体不断探索,它是证明NMX-compatible膜蛋白晶体确实可以获得。

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