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首页> 外文期刊>Aquaculture >Oxytetracycline depletion from skin-on fillet tissue of coho salmon fed oxytetracycline medicated feed in freshwater at temperatures less than 9 degrees C
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Oxytetracycline depletion from skin-on fillet tissue of coho salmon fed oxytetracycline medicated feed in freshwater at temperatures less than 9 degrees C

机译：在不到9摄氏度的温度下，从淡水中喂食土霉素鲑鱼加药饲料的鱼片的表皮组织中的土霉素去除

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摘要

Oxytetracycline (OTC) is a broad spectrum antibacterial agent approved in the USA for treating certain bacterial diseases in salmonids cultured in freshwater at temperatures greater than or equal to 9 degreesC. This study was conducted to provide the information necessary to expand the OTC label to include treatment of diseased salmonids cultured in freshwater at temperatures below 9 degreesC. The study was designed to treat juvenile coho salmon (Oncorhynchus kisutch) with OTC-medicated feed and determine the depletion of OTC from the skin-on fillet tissue. Oxytetracycline depletion was evaluated in juvenile coho salmon (weight range, 13-62 g) fed OTC-medicated feed at a rate of 88.2 mg OTC/kg body weight/day for 10 days. Pairs of skin-on fillets were taken from individual fish on days 4 and 10 during the treatment phase and on days 1, 4, 8, 14, and 19 during the depletion phase. Water temperatures during the study period ranged from 4.1 degreesC to 8.5 degreesC. The OTC concentrations in medicated feed and skin-on fillets were determined with high-performance liquid chromatography methods. The maximum mean OTC concentration in fillet tissue was 932 ng/g, I day after the last treatment and decreased to 32 ng/g 19 days after the last treatment. The log-linear loss of OTC from the fillet tissue was biphasic with a terminal phase half-life of 4.9 days.
机译：土霉素（OTC）是美国批准的广谱抗菌剂，用于治疗淡水在高于或等于9摄氏度的温度下培养的鲑鱼中的某些细菌性疾病。进行这项研究是为了提供扩展OTC标签所必需的信息，以包括处理在9摄氏度以下的淡水中培养的患病鲑鱼。这项研究旨在用OTC药物饲料处理幼年银大麻哈鱼（Oncorhynchus kisutch），并确定去皮鱼片组织中OTC的消耗。在以88.2 mg OTC / kg体重/天的速率饲喂10天的以OTC药物喂养的少年银大麻哈鱼（体重范围13-62 g）中评估了土霉素的消耗。在处理阶段的第4天和第10天以及在耗竭阶段的第1、4、8、14和19天从个体鱼中取出成对的鱼片。研究期间的水温范围为4.1摄氏度至8.5摄氏度。用高效液相色谱法测定了含药饲料和去皮鱼片中的OTC浓度。在上次治疗后的第1天，鱼片组织中OTC的最大平均浓度为932 ng / g，在最后一次治疗的第19天降至32 ng / g。圆角组织中OTC的对数线性损失是双相的，终相半衰期为4.9天。

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