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首页> 外文期刊>Journal of Cellular Physiology >Early endplate remodeling and skeletal muscle signaling events following rat hindlimb suspension
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Early endplate remodeling and skeletal muscle signaling events following rat hindlimb suspension

机译：早期终板重建和骨骼肌信号事件后大鼠后肢悬架

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摘要

Motor endplates naturally undergo continual morphological changes that are altered in response to changes in neuromuscular activity. This study examines the consequences of acute (6–12?hr) disuse following hindlimb suspension on rat soleus muscle endplate structural stability. We identify early changes in several key signaling events including markers of protein kinase activation, AMPK phosphorylation and autophagy markers which may play a role in endplate remodeling. Acute disuse does not change endplate fragmentation, however, it decreases both the individual fragments and the total endplate area. This decrease was accompanied by an increase in the mean fluorescence intensity from the nicotinic acetylcholine receptors which compensate the endplate area loss. Muscle disuse decreased phosphorylation of AMPK and its substrate ACC, and stimulated mTOR controlled protein synthesis pathway and stimulated autophagy. Our findings provide evidence that changes in endplate stability are accompanied by reduced AMPK phosphorylation and an increase in autophagy markers, and these changes are evident within hours of onset of skeletal muscle disuse.
机译：电机侧自然接受持续的形态变化中改变神经肌肉活动的变化。本研究考察了严重的后果(6 - 12 ?人力资源)停止使用后下肢悬挂大鼠比目鱼肌终板结构稳定性。初我们确定了几个关键的变化信号事件包括标记的蛋白质激酶激活AMPK磷酸化自噬标记可能扮演一个角色终板改造。终板碎片,然而,它也减少了两个人和总碎片终板区。平均荧光强度的增加从尼古丁乙酰胆碱受体终板区损失进行补偿。AMPK磷酸化及其下降衬底ACC,刺激mTOR的控制蛋白质合成途径和刺激自噬。变化都伴随着终板稳定减少AMPK磷酸化和增加自噬标记,这些变化是显而易见的在数小时内出现骨骼肌停止使用。

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