Sideroxylin (Callistemon lanceolatus) suppressed cell proliferation and increased apoptosis in ovarian cancer cells accompanied by mitochondrial dysfunction, the generation of reactive oxygen species, and an increase of lipid peroxidation

Park Sunwoo; Lim Whasun; Jeong WonsikBazer Fuller W.Lee DonghoSong Gwonhwa

首页> 外文期刊>Journal of Cellular Physiology >Sideroxylin (Callistemon lanceolatus) suppressed cell proliferation and increased apoptosis in ovarian cancer cells accompanied by mitochondrial dysfunction, the generation of reactive oxygen species, and an increase of lipid peroxidation

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Sideroxylin (Callistemon lanceolatus) suppressed cell proliferation and increased apoptosis in ovarian cancer cells accompanied by mitochondrial dysfunction, the generation of reactive oxygen species, and an increase of lipid peroxidation

机译：Sideroxylin (Callistemon飞刀)抑制细胞增殖和细胞凋亡增加卵巢癌细胞伴有线粒体功能障碍,活性氧的生成物种,增加脂质过氧化作用

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Sideroxylin is a C-methylated flavone isolated from Callistemon lanceolatus and exerts antimicrobial activity against Staphylococcus aureus. However, the anticancer effects of sideroxylin and its intracellular signaling mechanisms have not yet been identified. Results of our study showed that sideroxylin decreased cell proliferation and increased apoptosis, causing DNA fragmentation, depolarization of the mitochondrial membrane, the generation of reactive oxygen species, and an increase of lipid peroxidation in ovarian cancer cells (ES2 and OV90 cells). Additionally, sideroxylin activated the phosphorylation of ERK1/2, JNK, P38, and MAPK proteins and the use of LY294002, U0126, SB203580, and SP600125 to block their phosphorylation, respectively, in ES2 and OV90 cells. Collectively, the results of present study indicated that sideroxylin was a novel therapeutic agent to combat the proliferation of ovarian cancer cells through the induction of mitochondrial dysfunction and the activation of PI3K and MAPK signal transduction.

机译：Sideroxylin是C-methylated黄酮孤立从Callistemon飞刀和发挥对葡萄球菌抗菌活性葡萄球菌。sideroxylin及其细胞内信号机制尚未确定。我们的研究表明,sideroxylin下降细胞增殖和细胞凋亡增加,导致DNA碎片,去极化的线粒体膜的生成活性氧物种,增加脂质在卵巢癌细胞过氧化(ES2和OV90细胞)。ERK1/2的磷酸化,物,P38 MAPK蛋白质和使用LY294002, U0126,SB203580, SP600125阻止他们磷酸化,分别在ES2和OV90细胞。表明sideroxylin是一部小说治疗代理人应对的扩散通过诱导卵巢癌细胞线粒体功能障碍和激活PI3K和MAPK信号转导。

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来源
《Journal of Cellular Physiology》 |2018年第11期|8597-8604|共8页
作者
Park Sunwoo; Lim Whasun; Jeong WonsikBazer Fuller W.Lee DonghoSong Gwonhwa;
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作者单位

Gyeonggido Business & Sci Accelerator, Bioctr, Suwon, South Korea;

Texas A&M Univ, Ctr Anim Biotechnol & Genom, College Stn, TX USA;

Korea Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 02841, South KoreaKorea Univ, Coll Life Sci & Biotechnol, Dept Biosyst & Biotechnol, Seoul 02841, South KoreaCatholic Kwandong Univ, Dept Biomed Sci, Kangnung, South Korea;

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正文语种英语
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Callistemon citrinus; Signal Transduction; Lipid PeroxidationOvary Cancercancer cellDGCR14 geneCell ProliferationReactive Oxygen SpeciesApoptosis;

机译：Callistemon citrinus;信号转导;脂质PeroxidationOvary Cancercancer cellDGCR14geneCell ProliferationReactive氧气SpeciesApoptosis;

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Sideroxylin (Callistemon lanceolatus) suppressed cell proliferation and increased apoptosis in ovarian cancer cells accompanied by mitochondrial dysfunction, the generation of reactive oxygen species, and an increase of lipid peroxidation

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