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首页> 外文期刊>Journal of Cellular Physiology >Protective effects of curcumin against aflatoxicosis: A comprehensive review
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Protective effects of curcumin against aflatoxicosis: A comprehensive review

机译：姜黄素的保护作用黄曲霉毒素中毒:全面审查

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摘要

Aflatoxicosis is a deleterious medical condition that results from aflatoxins (AFs) or ochratoxins (OTs). Contamination with these toxins exerts detrimental effects on the liver, kidneys, reproductive organs, and also on immunological and cardiovascular systems. Aflatoxicosis is closely associated with overproduction of reactive oxygen species (ROS) as key contributors to oxidative and nitrosative stress responses, and subsequent damages to lipids, proteins, RNA, and DNA. The main target organ for AF toxicity is the liver, where DNA adducts, degranulation of endoplasmic reticulum, increased hepatic lipid peroxide, GSH depletion, mitochondrial dysfunction, and reduction of enzymatic and non‐enzymatic antioxidants are manifestations of aflatoxicosis. Curcuma longa L. (turmeric) is a medicinal plant widely utilized all over the world for culinary and phytomedical purposes. Considering the antioxidant characteristic of curcumin, the main active component of turmeric, this review is intended to critically summarize the available evidence supporting possible effectiveness of curcumin against aflatoxicosis. Curcumin can serve as a promising candidate for attenuation of the adverse consequences of aflatoxicosis, acting mainly through intrinsic antioxidant effects aroused from its structure, modulation of the immune system as reflected by interleukin‐1β and transforming growth factor‐β, and interfering with AF's biotransformation by cytochrome P450 isoenzymes CYP1A, CYP3A, CYP2A, CYP2B, and CYP2C.
机译：黄曲霉毒素中毒是一种有害的疾病结果从黄曲霉毒素(AFs)或赭曲霉素(OTs)。不利影响对肝脏、肾脏、生殖器官,也免疫和心血管系统。生产过剩的密切相关活性氧(ROS)的主要贡献者氧化和nitrosative应激反应,和随后的损害脂质、蛋白质、RNA,和DNA。DNA加合物的肝脏,脱粒内质网,增加肝脂质过氧化,谷胱甘肽耗竭,线粒体功能障碍,减少酶和非酶抗氧化剂的表现黄曲霉毒素中毒。药用植物被广泛的利用世界烹饪和phytomedical目的。考虑的抗氧化特性姜黄,姜黄的主要活性成分,本文旨在总结可用的证据支持姜黄素对黄曲霉毒素中毒的有效性。姜黄素可以作为一种很有前途的候选人衰减的不良后果黄曲霉毒素中毒,主要通过内在抗氧化作用引起的结构,免疫系统的调制所反映的白介素1β和转化生长因子β,应承担的和干扰AF的生物转化细胞色素P450同功酶CYP1A、CYP3A CYP2A,CYP2B, CYP2C。

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