...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Cellular Physiology >Claudin7b is required for the formation and function of inner ear in zebrafish
【24h】

Claudin7b is required for the formation and function of inner ear in zebrafish

机译：形成和Claudin7b是必需的在斑马鱼内耳功能

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Zebrafish has become an excellent model for studying the development and function of inner ear. We report here a zebrafish line in which claudin 7b ( cldn7b ) locus is interrupted by a Tol2 transposon at its first intron. The homozygous mutants have enlarged otocysts, smaller or no otoliths, slowly formed semicircular canals, and insensitiveness to sound stimulation. These abnormal phenotypes and hearing loss of inner ear could be mostly rescued by injection of cldn7b ‐mRNA into one‐cell stage homozygous mutant embryos. Mechanistically, cldn7b ‐deficiency interrupted the formation of apical junction complexes (AJCs) in otic epithelial cells of inner ear and the ion‐homeostasis of endolymph, which then led to the loss of proper contact between otoliths and normally developed hair cells in utricle and saccule or aberrant mechanosensory transduction. Thus, Cldn7b is essential for the formation and proper function of inner ear through its unique role in keeping an initial integrity of otic epithelia during zebrafish embryogenesis.
机译：斑马鱼已成为一个优秀的模型研究开发和内部的函数耳朵。claudin 7 b (cldn7b)轨迹是打断了Tol2转座子在其第一个内含子。纯合突变体有耳泡肿大,小或没有耳石,慢慢形成的的半规管,钝性的声音刺激。内耳听力损失的可能主要是获救,注入cldn7b mRNA为一个细胞阶段纯合突变体胚胎。cldn7b缺乏打断的形成顶端连接复合体(ajc)在耳内耳和上皮细胞离子量内淋巴的体内平衡,然后导致耳石和适当的接触通常发达毛细胞小囊小囊或异常mechanosensory转导。因此,Cldn7b形成和是至关重要的通过其独特的本征函数的内耳作用在维持最初的耳软骨的完整性在斑马鱼胚胎上皮细胞。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号