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首页> 外文期刊>Journal of Cellular Physiology >Angiogenesis biomarkers and their targeting ligands as potential targets for tumor angiogenesis
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Angiogenesis biomarkers and their targeting ligands as potential targets for tumor angiogenesis

机译：血管生成生物标志物及其目标配体作为肿瘤的潜在目标血管生成

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Angiogenesis is known as one of the hallmarks in cancer which could play a key role in providing oxygen and nutrients for tumor cells. It has been shown that tumor cannot grow without sufficient development of new blood vessels. Accordingly, targeting angiogenesis, especially endothelial cells, could be considered as a common therapeutic target in tumors and more investigation on already existing biomarkers and potentially new biomarkers of endothelial cells seems to be necessary in cancer therapy. Moreover, the use of effective targeting approaches such as proteins and peptides, aptamers, and small molecules is an important step for targeting biomarkers associated with endothelial cells and angiogenesis in cancer therapy. These agents are FDA approved, or are currently under investigation in pre‐clinical and clinical studies. Among various biomarkers for angiogenesis microRNAs are suitable candidates for target therapy. These molecules play key roles in tumor angiogenesis which exert their effect via targeting a variety of cellular and molecular pathways involved in tumor angiogenesis. Here, we summarize a variety of biomarkers which their expressions or their functions could change the function of endothelial cells in tumor microenvironments. Moreover, we highlighted various therapeutic agents which could target these biomarkers.
机译：血管生成的标志之一在提供癌症可以发挥关键作用肿瘤细胞的氧气和营养。表明,肿瘤的生长离不开充分的开发新的血管。针对血管生成,特别是内皮细胞,可能被认为是常见的在肿瘤治疗目标等等调查现有的生物标志物潜在的新生物标记的内皮细胞在癌症治疗似乎是必要的。此外,使用有效的目标蛋白质和多肽等方法,寡核苷酸适配子和小分子是一个重要的一步目标相关的生物标志物内皮细胞和肿瘤血管生成治疗。目前在临床和提前接受调查临床研究。血管生成小分子核糖核酸是合适的候选人为目标疗法。在肿瘤血管生成中发挥他们的角色通过针对各种细胞和效果分子途径参与肿瘤血管生成。他们的表情或生物标记可以改变的功能函数内皮细胞在肿瘤微环境。此外,我们强调各种治疗代理可以针对这些生物标记。

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