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首页> 外文期刊>Journal of Cellular Physiology >The novel role of pyrvinium in cancer therapy
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The novel role of pyrvinium in cancer therapy

机译：这部小说pyrvinium在癌症治疗中的作用

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Pyrvinium pamoate (PP) is a quinoline‐derived cyanine dye which was officially approved by FDA for its anthelmintic properties and therapeutic function against animal‐like protists such as Cryptosporidium parvum and Plasmodium falciparum in the 1950s. In the last 10 years, several studies have shown the novel activity of pyrvinium in tumor therapy. Some investigations have indicated that pyrvinium could delay or inhibit tumor cell proliferation in cancer models including colon, breast, lung and prostate cancer, and some hematological malignancies. In this review, we discuss multiple critical signaling pathways and mechanisms underlying the anticancer effects of PP. In details, pyrvinium acts through the following main mechanisms: (i) energy and autophagy depletion; and (ii) inhibition of Akt and Wnt‐β‐catenin‐dependent pathways. Interestingly, pyrvinium has also shown potent anti‐cancer stem cell activity. The overwhelming insights into the mechanism of anticancer properties of PP can help establishing novel and future anti‐tumor treatment strategies.
机译：Pyrvinium pamoate (PP)是一种喹啉派生花青染料正式FDA批准的打虫药属性和治疗函数对动物的类原生生物等隐孢子虫以及和恶性疟原虫在1950年代。研究表明,新颖的活动pyrvinium在肿瘤治疗。表明pyrvinium延迟或吗抑制肿瘤细胞增殖的肿瘤模型包括结肠癌、乳腺癌、肺癌和前列腺癌癌症和一些血液恶性肿瘤。本文,我们将讨论多个至关重要信号通路和机制抗癌效果的详细页,pyrvinium行为主要通过以下机制:(i)能源和自噬损耗;抑制一种蛋白激酶和Wntβ连环蛋白应承担的依赖通路。强有力的抗癌症干细胞活动。压倒性的见解的机理抗癌的属性页可以帮助建立小说和未来抗肿瘤治疗策略。

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