Therapeutic application of multipotent stem cells

Mirzaei Hamed; Sahebkar Amirhossein; Sichani Laleh ShiriMoridikia AbdullahNazari SaraSadri Nahand Javidsalehi HosseinStenvang JanMasoudifar AriaMirzaei Hamid R.Jaafari Mahmoud R.

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Therapeutic application of multipotent stem cells

机译：多功能干细胞的治疗应用

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Cell therapy is an emerging fields in the treatment of various diseases such as cardiovascular, pulmonary, hepatic, and neoplastic diseases. Stem cells are an integral tool for cell therapy. Multipotent stem cells are an important class of stem cells which have the ability to self‐renew through dividing and developing into multiple specific cell types in a specific tissue or organ. These cells are capable to activate or inhibit a sequence of cellular and molecular pathways leading to anti‐inflammatory and anti‐apoptotic effects which might contribute to the treatment of various diseases. It has been showed that multipotent stem cells exert their therapeutic effects via inhibition/activation of a sequence of cellular and molecular pathways. Although the advantages of multipotent stem cells are numerous, further investigation is still necessary to clarify the biology and safety of these cells before they could be considered as a potential treatment for different types of diseases. This review summarizes different features of multipotent stem cells including isolation, differentiation, and therapeutic applications.

机译：细胞疗法是一个新兴领域治疗各种疾病,如心血管、肺、肝和肿瘤疾病。细胞疗法的工具。一个重要的类的干细胞通过划分和地理自我更新能力发展成多个特定细胞类型特定的组织或器官。激活或抑制细胞和序列分子途径导致抗炎症这可能会造成和抗凋亡的影响各种疾病的治疗。表明,多功能干细胞发挥他们通过抑制/激活的治疗效果一系列的细胞和分子通路。虽然多功能干细胞的优势众多,进一步的研究仍然是吗需要澄清的生物学和安全这些细胞之前他们可以被视为一种潜在的治疗不同类型的疾病。功能的多功能干细胞,包括隔离、分化和治疗应用程序。

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来源
《Journal of Cellular Physiology》 |2018年第4期|2815-2823|共9页
作者
Mirzaei Hamed; Sahebkar Amirhossein; Sichani Laleh ShiriMoridikia AbdullahNazari SaraSadri Nahand Javidsalehi HosseinStenvang JanMasoudifar AriaMirzaei Hamid R.Jaafari Mahmoud R.;
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作者单位

Nanotechnology Research CenterMashhad University of Medical SciencesMashhad,Iran;

Department of Medical BiotechnologyMashhad University of Medical SciencesMashhad,Iran;

Biotechnology Research CenterMashhad University of Medical SciencesMashhad,IranFaculty of Basic ScienceUniversity of ShahrekordShahrekord,IranChemical Injuries Research CenterBaqiyatallah University of Medical SciencesTehran,IranFaculty of ScienceNorth Tehran Branch of Islamic Azad UniversityTehran,IranDepartment of VirologyIran University of Medical SciencesTehran,IranDepartment of Anatomical SciencesIsfahan University of Medical SciencesIsfahan,IranFaculty of Health and Medical SciencesUniversity of CopenhagenCopenhagen,DenmarkDepartment of Molecular Biotechnology, Cell Science Research CenterRoyan Institute forDepartment of ImmunologyTehran University of Medical SciencesTehran,Iran;

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正文语种英语
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关键词
Multipotent Stem Cell; Stem Cells; Therapeutic applicationsCell Therapy;

机译：多功能干细胞;干细胞;治疗applicationsCell疗法;

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Therapeutic application of multipotent stem cells

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