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Role of viruses in gastrointestinal cancer

机译：病毒在胃肠道癌症的作用

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摘要

Gastrointestinal cancers are a global public health problem, which represent a vast majority of all cancer‐caused deaths in both men and women. On the other hand, viral pathogens have been long implicated as etiological factors in the onset of certain human cancers, including gastrointestinal tumors. In this regard, Human Papilloma Virus (HPV), Epstein‐Barr Virus (EBV), and John Cunningham Virus (JCV) have been more strongly suggested to be involved in gastrointestinal carcinogenesis; so that, the association of HPV with oropharyngeal and anal cancers and also the association of EBV with gastric cancer have been etiologically confirmed by epidemiological and experimental investigations. Although, the association of other viruses is less evident, but may rely on co‐factors for their oncogenic roles. Therefore, to improve the prevention and treatment of these classes of cancer, their association with viral agents as potential risk factors should be investigated with care. In this respect, the present review has focused on the existing literature on the subject of viral involvement in gastrointestinal tumorgenesis, by covering and discussing various gastrointestinal cancers, corresponding viral agents and their oncogenic aspects and then summarizing evidences either supporting or rejecting a causal role of these pathogens in gastrointestinal malignancies.
机译：胃肠道癌症是一个全球公共健康问题,,它代表的是绝大多数所有的癌症导致男性和死亡女性。长期与病因因素某些人类癌症的发生,包括胃肠道肿瘤。乳头状瘤病毒(HPV),爱泼斯坦必经巴尔病毒(EBV),和约翰·坎宁安病毒(JCV)更多强烈建议参与胃肠癌形成;协会的人乳头状瘤病毒与口咽和肛门癌症也EBV的协会胃癌确诊病因流行病学和实验调查。其他病毒不太明显,但可能依赖公司提供有关因素的致癌作用。改进的预防和治疗与病毒类的癌症,它们的联系代理作为一个潜在的危险因素调查与护理。现在都集中在现有的审查有关这一课题的文献的病毒参与肠胃tumorgenesis、覆盖和讨论各种胃肠道癌症,相应的病毒制剂及其致癌然后总结方面的证据这些支持或反对一个因果的作用病原体在胃肠道恶性肿瘤。

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