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首页> 外文期刊>Journal of Cellular Physiology >Mesalazine treatment in organotypic culture of celiac patients: Comparative study with gluten free diet
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Mesalazine treatment in organotypic culture of celiac patients: Comparative study with gluten free diet

机译：Mesalazine治疗器官型培养的乳糜泻患者:比较研究与谷蛋白免费的饮食

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摘要

Given the central role of gluten in the pathogenesis of celiac disease (CD), a strict gluten‐free diet (GFD) is the only validated treatment able to restore epithelium integrity and eliminate risks of complications. The risk of gluten contamination and the persistence of inflammation, even in patients strictly adhering to GFD, may render this treatment not always effective claiming the necessity of different new solutions. Oxidative and nitrosative stress have been indicated to play a pathophysiological role in CD. Mesalazine (5‐ASA), a drug largely used in inflammatory bowel disease, has potent antinflammatory and antioxidant effects. In fact, mesalazine has been shown to decrease in vitro gluten induced cytokine response and it has been used in vivo in some refractory condition. However, its effect has never compared to that of GFD. The present study aimed to address this issue by comparing the ability of mesalazine and GFD in treating gluten‐induced inflammation and oxidative stress. These effects were studied on duodenal mucosa biopsy cultures from newly diagnosed CD patients, treated or not in vitro with mesalazine, and CD biopsy cultures from patients on gluten‐free diet for at least one year; and a cohort of controls constituted by healty subjects. On these models, the antioxidant cellular defences, the PPARγ, NF‐kB and NOS2 proteins levels were studied. This study shows that mesalazine is as effective as GFD in reducing oxidative burst and inducing PPARγ expression; moreover it resulted more effective than GFD in decreasing NF‐kB and NOS2 to the levels of controls.
机译：谷蛋白的核心作用乳糜泻(CD)的发病机理严格面筋免费饮食应承担(GFD)是唯一的验证治疗可以恢复上皮的完整性和消除并发症的风险。谷蛋白和持久性的污染炎症的发生,即使在患者严格遵循GFD,可能使这种治疗不总是正确的有效声称新的不同的必要性解决方案。表示发挥病理生理作用在CD。Mesalazine(5列车ASA),药物主要用于炎症性肠病,有力antinflammatory和抗氧化效果。mesalazine已被证明会降低体外谷蛋白诱导细胞因子反应和它体内一些耐火材料使用条件。然而,它从来没有比的影响GFD。通过比较mesalazine能力和问题GFD治疗蛋白诱导炎症和氧化应激。十二指肠粘膜活检文化新诊断CD患者,治疗体外与mesalazine CD活检文化病人在面筋免费饮食应承担的至少一个一年;受试者健康有好处。细胞防御,PPARγ,NF kB和NOS2蛋白质含量进行了研究。, mesalazine GFD一样有效减少氧化破裂,诱发PPARγ的表情;比减少GFD NF kB和NOS2水平的控制。

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