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Reactive oxygen species and colorectal cancer

机译：活性氧和结肠直肠癌

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摘要

Colorectal cancer (CRC) has become the fourth leading cause of cancer‐related death in the worldwide. It is urgent to find more effective therapeutic strategies for it. Reactive oxygen species (ROS) play multiple roles in normal cellular physiology processes. Thus, a certain level of ROS is essential to keep normal cellular function. However, the accumulation of ROS shows dual roles for cells, which is mainly dependent on the concentration of ROS, the origin of the cancer cell and the activated signaling pathways during tumor progression. In general, moderate level of ROS leads to cell damage, DNA mutation and inflammation, which promotes the initiation and development of cancer. Excessive high level of ROS induces cancer cell death, showing an anti‐cancer role. ROS are commonly higher in CRC cells than their normal counterpart cells. Therefore, it is possible that ROS induce cell death in cancer cells while not affecting the normal cells, demonstrating lower side effects. Besides, ROS also play a role in tumor microenvironment and drug resistance. These multiple roles of ROS make them a promising therapeutic target for cancer. To explore potential ROS‐target therapies against CRC, it is worth to comprehensively understanding the role of ROS in CRC and therapy. In this review, we mainly discuss the strategies of ROS in CRC therapy, including direct CRC cell target and indirect tumor environment target. In addition, the influences of ROS in drug resistance will also been discussed.
机译：结直肠癌(CRC)已经成为第四癌症检测相关死亡的主要原因在全球范围内。治疗策略。物种(ROS)在正常扮演多个角色细胞生理过程。ROS水平保持正常的细胞是至关重要的函数。细胞的双重角色,主要是相关的ROS浓度,的起源癌细胞和激活的信号通路在肿瘤进展。ROS水平会导致细胞损伤、DNA突变和炎症,促进启动和癌症的发展。活性氧诱发癌症的细胞死亡,显示一个抗癌症的作用。细胞比正常细胞。因此,它是可能的,活性氧诱导细胞死于肿瘤细胞而不影响正常细胞,降低副作用。此外,ROS也在肿瘤中发挥作用微环境和耐药性。ROS的多个角色使他们一个有前途的针对癌症的治疗目标。潜在的活性氧检测目标对CRC疗法,它是价值,全面理解所扮演的角色ROS的CRC和治疗。主要讨论ROS在CRC的策略治疗,包括直接目标和CRC细胞间接肿瘤环境目标。ROS在耐药性的影响也进行了讨论。

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