Roles of lipocalin 2 and adiponectin in iron overload cardiomyopathy

Siri‐Angkul Natthaphat; Chattipakorn Siriporn C.; Chattipakorn Nipon

首页> 外文期刊>Journal of Cellular Physiology >Roles of lipocalin 2 and adiponectin in iron overload cardiomyopathy

【24h】

Roles of lipocalin 2 and adiponectin in iron overload cardiomyopathy

机译：角色lipocalin 2和脂联素的铁过载心肌病

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Thalassemia is among the most common genetic diseases worldwide. Ineffective erythropoiesis, chronic hemolysis, and regular blood transfusion in thalassemia patients lead to increased iron burden. Iron overload cardiomyopathy is the most severe co‐morbidity and most common cause of mortality in thalassemia patients. Although its associated mechanisms are still not completely understood, cellular iron mishandling, chronic inflammation, and oxidative stress appear to be the key processes involved. In order to acquire a more comprehensive insight of the impact of cardiac iron overload, these alterations need to be intensively investigated. This comprehensive mini‐review focuses on two emergent molecules which have been shown to potentially play significant roles in iron overload cardiomyopathy. These two molecules are an iron‐transporting protein, lipocalin 2, and an anti‐inflammatory adipokine, adiponectin. Reports from in vitro and in vivo studies are comprehensively summarized. Clinical studies examining the roles of these molecules in thalassemia patients are also presented and discussed.

机译：地中海贫血是最常见的基因之一全球疾病。慢性溶血,常规输血地中海贫血患者导致铁负担。严重的高发病率和最常见的原因地中海贫血患者的死亡率。相关的机制仍不完全理解,细胞铁处理不当,慢性炎症和氧化应激出现过程的关键。更全面的观点的影响心脏铁过载,这些改变需要深入调查。迷你回顾关注两个紧急分子已被证明可能玩吗铁过载的重要角色心肌病。铁列车运输蛋白质,lipocalin 2,和一个抗高炎症adipokine脂联素。从体外和体内研究全面总结。研究这些分子的角色地中海贫血病人也提出了和进行了讨论。

著录项

来源
《Journal of Cellular Physiology》 |2018年第7期|5104-5111|共8页
作者
Siri‐Angkul Natthaphat; Chattipakorn Siriporn C.; Chattipakorn Nipon;
展开▼
作者单位

Faculty of MedicineChiang Mai UniversityChiang Mai,Thailand;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
Thalassemia; Cardiomyopathies; AdiponectinBlood TransfusionLipocalin-2Cardiovascular DiseasesIron OverloadHeart;

机译：TransfusionLipocalin-2Cardiovascular DiseasesIronOverloadHeart;

相似文献

外文文献
中文文献
专利

1. Natural Iron Chelators: An Orthomolecular Approach to Treat Iron Overload and Its Related Diseases [J] . Asmae Mesbahi El Aouame, Karima El Akkaly, Ilyes Baghli 食品科学与工程：英文版 . 2020,第001期
2. The lipocalins retinol-binding protein-4, lipocalin-2 and lipocalin-type prostaglandin D2-synthase correlate with markers of inflammatory activity, alcohol intake and blood lipids, but not with insulin sensitivity in metabolically healthy 58-year-old Swedish men. [J] . Wallenius V, Elias E, Bergstrom GM, Experimental and clinical endocrinology and diabetes: Official journal, German Society of Endocrinology [and] German Diabetes Association . 2011,第2期

机译：在58岁新陈代谢健康的瑞典男性中，lipocalins视黄醇结合蛋白4，lipocalin-2和lipocalin型前列腺素D2合酶与炎症活动，酒精摄入和血脂标记有关，但与胰岛素敏感性无关。
3. The management of hand injuries in a Role 2 enhanced or Role 3 facility: Part 2. [J] . P M Guyver, J M Baden, D M Standley, Journal of the Royal Naval Medical Service . 2012,第1期

机译：在Role 2增强型或Role 3设施中的手部伤害管理：第2部分。
4. The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1 [J] . Apostolovic D., Sanchez-Vidaurre S., Waden K., Allergy . 2016,第10期

机译：猫lipocalin Fel d 7及其与狗lipocalin Can f 1的交叉反应
5. Prediction of loading system (shovel) productivity based up on large fragmented rock caused by blasting operation in Gol-e-Gohar iron mine of Iran [C] . M. Osanloo, A. Hekmat International Symposium on Mine Planning and Equipment Selection . 2004

机译：基于大型碎裂岩石引起的伊朗GOL-E-Gohar Iron Iron Iron Iron Iron Iron Iron Iron Ir Iron Iron Ir Iron Iron Ir Iron Ir Iron Ir Iron Ir Iron Ir Iron Ir Iron Ir Iron Iron Ir Iron Iron Ir Iron Iron Ir Iron Iron Iron Iron Iron Iron Ir Iron Iron Ir Iron Ir Iron Iron Ir Iron Ir Iron Iron Iron Ir Iron Iron Iron Iron Iron Irance的预测
6. PART I. THE DETECTION OF ELECTRON POLARIZATION BY MOLLER SCATTERING. PARTII. ENERGY LEVELS IN THE NEAR-HARMONIC NUCLEI IRON-56, IRON-58 AND NICKEL-60. [D] . LEVINE, NATHAN. 1958

机译：第一部分：利用莫勒散射法检测电子极化。第二部分近钟形核IRON-56，IRON-58和NICKEL-60的能量水平。
7. A comparison of performance of Deca Iron and Triple Deca Iron ultra-triathletes [O] . Beat Knechtle, Thomas Rosemann, Romuald Lepers, -1

机译：Deca Iron和Triple Deca Iron超铁人三项运动员的性能比较
8. ジョウケンスウセイヤクツキセイテイチギョウレツキンジモンダイニツイテサイテキカシュホウノリロントオウヨウノツナガリ [O] . 田中未来, 中田和秀 2013

机译：龙宫Se S S chi Go Kin ji Mon Ni ite ite ika Shu Nor iron iron iron Tsu Tsu
9. Detrimental role of hydrogen on the corrosion rate of zirconium alloys. (Etude du role nefaste de l'hydrogene sur la cinetique de corrosion des alliages de zirconium) [R] . Blat, M. , Noel, D. 1995

机译：氢对锆合金腐蚀速率的不利影响。（Etude du role nefaste de l'hydrogene sur la cinetique de corrosion des alliages de zirconium）

Roles of lipocalin 2 and adiponectin in iron overload cardiomyopathy

摘要

著录项

相似文献

相关主题

期刊订阅