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首页> 外文期刊>Archives of Andrology: An International Journal >Male fertility of kidney transplant patients with one to ten years of evolution using a conventional immunosuppressive regimen.
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Male fertility of kidney transplant patients with one to ten years of evolution using a conventional immunosuppressive regimen.

机译：使用传统的免疫抑制方案，肾脏移植患者的男性生育能力需要1至10年的演变。

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摘要

The reproductive functions and hormone serum levels of 55 male kidney transplant recipients were assessed. Patients underwent peritoneal dialysis before transplantation and were given immunosuppressive therapy afterward for 1 to 10 years. Spermatobioscopies were performed, and serum urea, creatinine, luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), and testosterone (T) levels were determined. Average serum urea and creatinine levels were 54.6+/-1.4 and 3+/-1.3 mg/dL, respectively. The average serum hormone levels were 3.2+/-2 mIU/mL (LH), 6.3+/-1.7 mIU/mL (FSH), 11.7+/-1.5 ng/mL (PRL), and 23+/-1.4 pg/mL (T). Libido reduction was reported in 88% of patients within 8 months following transplantation. Normozoospermia was seen in 47.3% of the patients, asthenozoospermia in 18.2% oligozoospermia in 14.5%, while oligoteratozoospermia, asthenoteratozoospermia, oligoasthenozoospermia, oligoasthenoteratozoospermia, and azoospermia were seen in the rest. Twenty-six patients procreated one or more children after transplantation; 36.6% of those children were premature but nonetheless healthy. No association existed between the post-transplant period and urea or creatinine levels. Significant differences were found when LH levels and sperm motility were assessed. Also, statistically significant differences were found when duration of dialysis, FSH levels, sperm counts, morphology, and motility between posttransplant fertile and infertile patients were correlated. In conclusion, there was an adequate recovery of sexual and reproductive functions in most patients subjected to kidney transplantation and conventional immunosuppressants.
机译：评估了55名男性肾脏移植受者的生殖功能和激素血清水平。患者在移植前进行了腹膜透析，之后接受了免疫抑制治疗1至10年。进行精子活检，并测定血清尿素，肌酐，黄体生成激素（LH），促卵泡激素（FSH），催乳素（PRL）和睾丸激素（T）水平。平均血清尿素和肌酐水平分别为54.6 +/- 1.4和3 +/- 1.3 mg / dL。平均血清激素水平为3.2 +/- 2 mIU / mL（LH），6.3 +/- 1.7 mIU / mL（FSH），11.7 +/- 1.5 ng / mL（PRL）和23 +/- 1.4 pg / mL毫升（T）。据报道，移植后8个月内有88％的患者减少了性欲。正常精子症占47.3％，弱精子症占18.2％，少精子症占14.5％，而少精子精子症，无精子症，少精子症，少精子症和无精子症。 26例患者在移植后生育了一个或多个孩子。这些孩子中有36.6％早产，但仍然健康。移植后的时期与尿素或肌酐水平之间没有关联。当评估LH水平和精子活力时，发现显着差异。同样，当将移植后可育和不育患者之间的透析时间，FSH水平，精子数量，形态和运动性相关时，发现统计学上的显着差异。总之，在大多数接受肾脏移植和常规免疫抑制剂治疗的患者中，性功能和生殖功能均得到了适当的恢复。

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