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首页> 外文期刊>Genetic testing and molecular biomarkers >Analysis of the Impact of Common Polymorphisms of the FTO and MC4R Genes with the Risk of Severe Obesity in Saudi Arabian Population
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Analysis of the Impact of Common Polymorphisms of the FTO and MC4R Genes with the Risk of Severe Obesity in Saudi Arabian Population

机译：分析常见的多态性的影响FTO中的基因与严重的风险在沙特阿拉伯人口肥胖

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摘要

Background: Obesity has reached epidemic proportions worldwide resulting in a serious public health problem. In Saudi Arabia, 28.7% of the population is obese due largely to the adoption of western dietary patterns over the last decade. The Fat-mass and obesity associated (FTO) and melanocortin-4 receptor (MC4R) genes are ubiquitously expressed in the brain and pancreatic islets, and are the main link between the central nervous system and energy homeostasis based on food intake and energy expenditure. Genetic variants in the FTO and MC4R gene have been strongly associated with an increased obesity risk. Aim: To identify novel mutations in the MC4R gene and to perform correlation analysis of the known variants rs9939609 and rs1421085 in the FTO gene and rs17782313 near the MC4R gene in an obese Saudi population. Materials and Methods: A total of 136 obese patients and 104 healthy controls from King Fahd Hospital, Al-Khobar, were genotyped for single-nucleotide polymorphisms within or near the FTO and MC4R genes using the TaqMan assay. Leptin levels were determined by enzyme-linked immunosorbent assay. Targeted sequencing of MC4R exon was done by Sanger sequencing method. Results: The study included 58 obese males and 78 obese females with a mean age of 39.7812.77 years and a mean body mass index (BMI) of 42.65 +/- 9.03kg/m(2). A significant increase in the levels of leptin and triglycerides was associated with an increase of BMI. Other factors such as lactate dehydrogenase, gamma-glutamyltransferase, and high-density lipoprotein were also significantly higher in the severely obese cohort. The FTO polymorphisms were associated with a significantly increased risk for obesity and in BMI-stratified cohort, rs9939609 (T/A: odds ratio [OR]=1.73, p=0.007) and rs1421085 (T/C: OR=1.56, p=0.03) showed even stronger association. Genotyping for the near MC4R, polymorphism, rs17782313 revealed an association with moderately obese patients (T/C: OR=1.73, p=0.038). Conclusion: The
机译：背景:肥胖已经达到流行病比例在世界范围内导致严重公共卫生问题。肥胖的主要原因是人口采用的西方饮食模式最后的十年。(FTO)和melanocortin-4受体(中的)基因广泛表达于大脑和胰岛细胞,是主要的联系中枢神经系统和能源体内平衡基于食物摄入和能量消耗。FTO基因变异和中的基因是与增加密切相关肥胖的风险。中的基因并进行相关分析已知的变异rs9939609 rs1421085附近的FTO基因和rs17782313中的基因一个肥胖的沙特人口。总共有136肥胖患者和104名健康Al-Khobar,控制医院法赫德国王基因的单核苷酸多态性内或附近的FTO基因中的使用TaqMan化验。酶联免疫吸附试验。序列中的外显子是由桑格完成的测序方法。肥胖的男性和78名肥胖女性的平均年龄39.7812.77年平均身体质量指数(BMI) 42.65 + / - 9.03公斤/米(2)。增加的瘦素和水平甘油三酯与增加有关BMI。gamma-glutamyltransferase,高密度脂蛋白也显著提高严重肥胖人群。风险显著增加对肥胖症BMI-stratified队列,rs9939609 (T / A:比值比(或)= 1.73,p = 0.007)和rs1421085 (T / C: = 1.56, p = 0.03)显示更强的协会。中的多态性,rs17782313透露与中度肥胖病人(T / C:或= 1.73,p = 0.038)。

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