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首页> 外文期刊>Genetic testing and molecular biomarkers >The Association Between XPG Gene Polymorphism and Gastric Cancer Risk
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The Association Between XPG Gene Polymorphism and Gastric Cancer Risk

机译：XPG基因多态性之间的关系胃癌的风险

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Purpose: Studies exploring the association between the Xeroderma pigmentosum group G (XPG) gene polymorphisms and gastric cancer (GC) risk provide conflicting findings. Thus, this meta-analysis was performed. Materials and Methods: The PubMed and EMBASE databases were comprehensively searched to identify studies for the inclusion in the meta-analysis. The strength of the association was evaluated by calculating pooled odds ratios and 95% confidence intervals. Results: Nine case-control studies involving 3540 cases and 3953 controls were included in the meta-analysis, which revealed that the XPG rs751402 polymorphism is positively associated with GC risk and could be viewed as a risk factor of GC in three genetic models. Conclusion: The XPG gene rs751402 polymorphism is associated with an increased risk of GC in Chinese Han populations. This finding should be verified by larger studies that include additional ethnic groups.
机译：目的:研究探索之间的联系着色性干皮病组G (XPG)基因多态性与胃癌(GC)的风险提供了相互矛盾的结果。荟萃分析。方法:PubMed和EMBASE数据库全面搜索识别研究包含在荟萃分析。协会由计算评估集中优势比和95%置信区间。结果:九个病例对照研究,涉及3540人病例和3953控制被包含在荟萃分析显示XPGrs751402多态性是呈正相关的GC的风险和可能被视为一个风险因素GC的三种遗传模型。rs751402 XPG基因多态性有关在中国汉族GC的风险增加人群。更大规模的研究,包括额外的民族组。

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