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首页> 外文期刊>Genetic testing and molecular biomarkers >Association of IL-10-1082A/G Polymorphism with Ischemic Stroke: Evidence from a Case-Control Study to an Updated Meta-Analysis
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Association of IL-10-1082A/G Polymorphism with Ischemic Stroke: Evidence from a Case-Control Study to an Updated Meta-Analysis

机译：协会的il - 10 - 1082 a / G多态性缺血性中风:证据从一个病例对照研究一个更新的荟萃分析

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Background and Aims: Interleukin-10 (IL-10) plays a vital part in the pathophysiology of vascular inflammation. Several studies have investigated the potential association between the IL-10-1082A/G polymorphism and the risk of ischemic stroke where the inflammatory process is involved, but the conclusions have been inconsistent. Methods: Three hundred eighty-six ischemic stroke patients and 386 healthy controls were recruited in the study. Genotyping was conducted by using the polymerase chain reaction-ligation detection reaction method. A meta-analysis was then performed by pooling our data with previous published studies. Results: In our case-control study, a lack of association was revealed between IL-10-1082A/G and ischemic stroke (p>0.05). When combined with previous studies, however, a significant relationship between IL-10-1082A/G and ischemic stroke risk was found (G vs. A: OR=0.73, 95% CI=0.60-0.88, p<0.01; GG vs. AA: OR=0.61, 95% CI=0.49-0.76, p<0.01; GG+AG vs. AA: OR=0.70, 95% CI=0.54-0.91, p<0.01; GG vs. AG+AA: OR=0.68, 95% CI=0.52-0.89, p<0.01), as well as in subgroup analyses. Sensitivity analysis and publication bias assessment supported the reliability of the results from the meta-analysis. Conclusions: Evidence from a case-control study to an updated meta-analysis suggests that the IL-10-1082A/G polymorphism is associated with ischemic stroke susceptibility.
机译：背景和目的:白细胞介素- 10”(il - 10)血管病理生理学的重要组成部分炎症。潜在的关联il - 10 - 1082 a / G多态性和的风险缺血性中风的炎症过程涉及,但结论不一致的。缺血性中风患者和386名健康对照组在研究招募了。利用聚合酶链进行reaction-ligation检测反应的方法。荟萃分析是由池我们数据与先前发表的研究。我们的病例对照研究,缺乏协会显示il - 10 - 1082 a / G和缺血中风(p > 0.05)。研究,然而,一个重要的关系il - 10 - 1082 a / G和缺血性中风的风险被发现(G与答:= 0.73,95% CI -0.88 = 0.60,p < 0.01;p < 0.01;p < 0.01;p < 0.01),以及在子群分析。敏感性分析和发表偏倚支持的可靠性评估荟萃分析的结果。证据从一个更新的病例对照研究荟萃分析表明,il - 10 - 1082 a / G多态性与缺血性中风相关联易感性。

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