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首页> 外文期刊>Genetic testing and molecular biomarkers >Association of Three Single Nucleotide Polymorphisms in MTR and MTRR Genes with Lung Cancer in a Turkish Population
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Association of Three Single Nucleotide Polymorphisms in MTR and MTRR Genes with Lung Cancer in a Turkish Population

机译:协会的三个单核苷酸在地铁和MTRR基因多态性与肺癌症在土耳其人口

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摘要

Aims: Folate metabolism plays a critical role in DNA methylation and synthesis. Polymorphisms in folate metabolism may affect enzyme activities and thereby affect the cancer risk. Methionine synthase (MTR) and methionine synthase reductase (MTRR) are critical enzymes for the folate cycle. In this study, possible associations between genetic variabilities in MTR and MTRR and susceptibility to lung cancer (LC) were investigated in a Turkish population.
机译:目的:叶酸代谢中起关键作用DNA甲基化和合成。叶酸代谢可能影响酶活性从而影响患癌症的风险。合酶(地铁)和蛋氨酸合成酶还原酶(MTRR)叶酸周期的关键酶。在这项研究中,可能的关系在地铁和MTRR和遗传可变性对肺癌易感性(LC)在土耳其人口调查。

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