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首页> 外文期刊>Archives of Iranian medicine >Gastrointestinal and non-gastrointestinal presentation in patients with celiac disease
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Gastrointestinal and non-gastrointestinal presentation in patients with celiac disease

机译：腹腔疾病患者的胃肠道和非胃肠道表现

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摘要

Background: Celiac disease (CD) may have a variety of different presentations. This study has aimed to explore the prevalence of gastrointestinal (GI) and non-GI symptoms in patients with CD according to data collected in Italy and Romania (Europe) and Iran (Middle East). Methods: This is a retrospective cross-sectional study conducted in Iran, Romania and Italy with data collection during the period from May 2009 - May 2011. For each center we included only patients with CD that was confirmed by endoscopy, small bowel biopsies and positive serology. GI symptoms such as abdominal pain, diarrhea, constipation, nausea and vomiting, weight loss and flatulence, as well as additional signs and symptoms of iron deficiency anemia (IDA), osteoporosis, hypertransaminasemia, and other related abnormalities were collected. Results: Overall, 323 women and 127 men, whose mean age at diagnosis was 34.2 ± 16.47 years were included in this study. Of these, 157 subjects (34.9%) reported at least one GI symptom. The majority of cases had the following primary presenting GI symptoms: diarrhea (13.6%), dyspepsia and constipation (4.0%). Other disease symptoms were reported by 168 (37.3%) patients. The most presenting non-GI symptoms in the majority of cases were anemia (20.7%) and osteopenia (6%). There were statistically significant differences between the majority of symptoms when we compared the reported clinical symptoms from different countries. Conclusion: This study indicated that upper abdominal disorders such as abdominal pain and dyspepsia were the most common primary complaints among European patients, whereas Iranian patients had complaints of diarrhea and bloating as the classic presentations of CD. For non-GI symptoms, anemia was the most frequent complaint for both Iranian and Italian patients; however it was significantly higher in Iranians.
机译：背景：腹腔疾病（CD）可能有多种不同的表现。这项研究旨在根据在意大利和罗马尼亚（欧洲）和伊朗（中东）收集的数据，探讨CD患者的胃肠道（GI）和非胃肠道症状的患病率。方法：这是一项回顾性横断面研究，在2009年5月至2011年5月期间在伊朗，罗马尼亚和意大利进行了数据收集。对于每个中心，我们仅包括经内窥镜检查，小肠活检和阳性证实的CD患者。血清学。收集了胃肠道症状，如腹痛，腹泻，便秘，恶心和呕吐，体重减轻和肠胃气胀，以及缺铁性贫血（IDA），骨质疏松症，高转氨血症和其他相关异常的其他体征和症状。结果：本研究共纳入323名女性和127名男性，其平均诊断年龄为34.2±16.47岁。其中157名受试者（34.9％）报告了至少一种胃肠道症状。大多数病例具有以下主要的胃肠道症状：腹泻（13.6％），消化不良和便秘（4.0％）。 168（37.3％）位患者报告了其他疾病症状。在大多数情况下，最常见的非胃肠道症状是贫血（20.7％）和骨质减少（6％）。当我们比较来自不同国家的报告临床症状时，大多数症状之间在统计学上有显着差异。结论：这项研究表明，上腹部疾病（如腹痛和消化不良）是欧洲患者中最常见的主要主诉，而伊朗患者则以腹泻和腹胀为主诉，是CD的经典表现。对于非胃肠道症状，贫血是伊朗和意大利患者最常见的主诉。但是在伊朗人中这个比例要高得多。

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