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首页> 外文期刊>Archives of Iranian medicine >Clinical presentation and etiologic factors of hirsutism in premenopausal Iranian women.
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Clinical presentation and etiologic factors of hirsutism in premenopausal Iranian women.

机译：伊朗绝经前妇女多毛症的临床表现和病因。

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BACKGROUND: Hirsutism is a common clinical condition with different etiologies. Many of these patients have frank or subclinical abnormalities in the adrenal and ovarian steroidogenesis. The disease may be associated with other clinical signs of hyperandrogenism. The objective of this study was to investigate the clinical features of hirsutism and its etiologic factors in premenopausal Iranian women. METHODS: In a cross-sectional study, 790 consecutive premenopausal women referred to the dermatology Clinics of Hazrat-e Rasool and Firoozgar University Hospitals and three private dermatology clinics during 2001 - 2003 with the clinical diagnosis of hirsutism were studied. All patients underwent detailed clinical assessment and transabdominal ultrasonography of the ovaries. Endocrinologic work-up was performed for 285 patients. RESULTS: Hirsutism was mild in 65%, moderate in 32.5%, and severe in 2.5% of the patients. Positive family history was found in 56.2%. Hormonal studies revealed some abnormalities in 35.2% of the patients. Coexisting medical conditions included acne in 70% of the patients, menstrual irregularity in 38.6%, androgenic alopecia in 21.3%, obesity in 6.5%, acanthosis nigricans in 4.9%, and diabetes in 0.6% of the patients. Etiology of hirsutism was identified as polycystic ovary syndrome (62.53%), idiopathic (35.19%), congenital adrenal hyperplasia (0.38%), prolactinoma (0.13%), and undetermined (1.77%). Polycystic ovary syndrome was diagnosed more frequently in women with menstrual irregularity than eumenorrheic patients (97.70% vs. 40.41%, P < 0.001). CONCLUSIONS: Hirsute patients frequently have either elevated androgen levels or clinical conditions associated with hyperandrogenemia. Eumenorrhea does not rule out endocrine abnormality and particularly polycystic ovary syndrome which is a common cause of hirsutism. We recommend performing endocrinologic work up, investigation of coexisting hyperandrogenic states, and evaluation of polycystic ovary syndrome in all patients with hirsutism.
机译：背景：多毛症是一种常见的临床病因，病因不同。这些患者中有许多在肾上腺和卵巢类固醇生成方面存在坦率或亚临床异常。该疾病可能与高雄激素血症的其他临床症状有关。这项研究的目的是调查多毛症的临床特征及其病因在伊朗绝经前的妇女中。方法：在一项横断面研究中，研究了790名连续绝经前妇女在2001年至2003年间转诊至Hazrat-e Rasool和Firoozgar University Hospitals的皮肤病学诊所以及三间私人皮肤病诊所，并进行了多毛症的临床诊断。所有患者均接受详细的临床评估和经腹部超声检查卵巢。对285例患者进行了内分泌检查。结果：多毛症患者的轻度为65％，中度为32.5％，重度为2.5％。阳性家族史发现率为56.2％。激素研究显示35.2％的患者有一些异常。并存的医学疾病包括痤疮70％，月经不调38.6％，雄激素性脱发21.3％，肥胖6.5％，黑棘皮病4.9％和糖尿病0.6％。多毛症的病因被确定为多囊卵巢综合征（62.53％），特发性（35.19％），先天性肾上腺增生（0.38％），泌乳素瘤（0.13％）和未定（1.77％）。月经不调的女性多发性卵巢综合征的诊断率要高于非漏诊的女性（97.70％比40.41％，P <0.001）。结论：肥胖患者经常患有雄激素水平升高或与高雄激素血症相关的临床疾病。漏尿不排除内分泌异常，尤其是多囊卵巢综合症，多囊卵巢综合症是多毛症的常见原因。我们建议对所有多毛症患者进行内分泌检查，共存的高雄激素状态调查以及多囊卵巢综合征的评估。

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