Leiomyosarcoma of the larynx as a local relapse of squamous cell carcinoma--report of an unusual case.

Volker HU; Zettl A; Haralambieva EBlume BHagen RMuller Hermelink HKScheich M

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Leiomyosarcoma of the larynx as a local relapse of squamous cell carcinoma--report of an unusual case.

机译：平滑肌肉瘤的喉局部复发鳞状细胞癌,报告一个不寻常的的情况。

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BACKGROUND: The authors report on leiomyosarcoma after previously treated squamous cell carcinoma (SCC) at the glottis. METHODS: Primary tumor and relapses were investigated morphologically, immunohistochemically, and with molecular methods. RESULTS: The SCC was typical, but few cells showed a spindle-shaped pattern. The relapse tumor was a spindle-shaped and epitheloid tumor with the morphological and immunohistochemical appearance of leiomyosarcoma (sm-actin+, desmin+, caldesmon+, vimentin+, keratin-).The comparative genomic hybridization (CGH) revealed some gains and losses in the leiomyosarcoma. Because of altered material, the investigation failed in the primary. A fluorescence in situ hybridization (5p) focally detected 3 chromosmomal copies, corresponding to gains on 5p in CGH of leiomyosarcoma. CONCLUSION: Leiomyosarcoma after SCC is very uncommon. A connection between both seems likely in this case. Transdifferentiation, also seen in other tumors or carcinosarcomas, could be based on aberrant differentiation of a pluripotent stem cell.

机译：背景:作者报告平滑肌肉瘤此前鳞状细胞癌治疗(SCC)声门。复发了形态,免疫组织化学和分子方法。细胞表现出纺锤状模式。复发肿瘤是一个纺锤状,epitheloid肿瘤与形态免疫组织化学的平滑肌肉瘤(肌间线蛋白+ sm-actin + caldesmon +,波形蛋白+,角蛋白-)。(CGH)透露了一些收益和损失平滑肌肉瘤。调查在初选中失败。荧光原位杂交(5便士)信用证欺诈发现3 chromosmomal册,对应收益5 p CGH平滑肌肉瘤。平滑肌肉瘤在鳞状细胞癌非常罕见。似乎在这之间的联系的情况。可以基于肿瘤或癌肉瘤异常分化的多能干细胞细胞。

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《Head and neck: Journal for the sciences and specialities of the head and neck》 |2010年第5期|679-683|共5页
作者
Volker HU; Zettl A; Haralambieva EBlume BHagen RMuller Hermelink HKScheich M;
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作者单位

Institute of Pathology, University Wurzburg, Germany.;

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原文格式 PDF
正文语种英语
中图分类头部及神经外科学;
关键词
Leiomyosarcoma; Relapse; Chromosome 5 Short ArmCarcinosarcomaPluripotent Stem CellsGainLarynxIn Situ Hybridization, Fluorescent;

机译：平滑肌肉瘤;复发;5号染色体短ArmCarcinosarcomaPluripotent茎CellsGainLarynxIn原位杂交,荧光;

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2. LOSS OF HETEROZYGOSITY ON CHROMOSOME 13 IN SQUAMOUS CELL CARCINOMAS OF THE LARYNX [J] . Bai Sujuan, Zhang Xue, Wang Jun, 中国癌症研究（英文版） . 1998,第001期
3. Adu; Aged;; Aged, 80 and over;; Cadherins;; Carcinoma, Squamous Cell;; Cell Nucleus;; Cytoplasm;; Female;; Humans;; Laryngeal Neoplasms;; Male;; Middle Aged;; Neoplasm Staging;; Protein-Serine-Threonine Kinases;; Proto-Oncogene Proteins c-akt;; Retrospective Studies;; beta Catenin;; *成年人;; 老年人;; 老年人, 80以上;; 钙粘着糖蛋白类;; 癌, 鳞状细胞;; 细胞核;; 细胞质;; 喉肿瘤;; 肿瘤分期;; 蛋白质丝氨酸苏氨酸激酶;; 回顾性研究 [J] . Acta Anaesthesiologica Scandinavica . 2009,第10期

机译：Adu; Aged;; Aged, 80 and over;; Cadherins;; Carcinoma, Squamous Cell;; Cell Nucleus;; Cytoplasm;; Female;; Humans;; Laryngeal Neoplasms;; Male;; Middle Aged;; Neoplasm Staging;; Protein-Serine-Threonine Kinases;; Proto-Oncogene Proteins c-akt;; Retrospective Studies;; beta Catenin;; *成年人;; 老年人;; 老年人, 80以上;; 钙粘着糖蛋白类;; 癌, 鳞状细胞;; 细胞核;; 细胞质;; 喉肿瘤;; 肿瘤分期;; 蛋白质丝氨酸苏氨酸激酶;; 回顾性研究
4. Leiomyosarcoma of Larynx as a Metachronous Tumor of Squamous Cell Carcinoma: An Unusual Case [J] . Ismi Onur, Arpaci Rabia Bozdogan, Puturgeli Tugce, Journal of voice: official journal of the Voice Foundation . 2016,第2期

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机译：subamolide B Isolated from medicinal plantCinnamomum subavenium Induces Cytotoxicity in HumanCutaneous squamous Cell Carcinoma Cells throughmitochondrial and CHOp-Dependent Cell Death pathways

Leiomyosarcoma of the larynx as a local relapse of squamous cell carcinoma--report of an unusual case.

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