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首页> 外文期刊>Archives of cardiovascular diseases. Supplements >Management of Takotsubo cardiomyopathy in non-academic hospitals in France: The Observational French SyndromEs of TakoTsubo (OFSETT) study
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Management of Takotsubo cardiomyopathy in non-academic hospitals in France: The Observational French SyndromEs of TakoTsubo (OFSETT) study

机译：法国非学术医院对Takotsubo心肌病的管理：TakoTsubo的法国观察综合征（OFSETT）研究

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Summary Background. — Takotsubo cardiomyopathy (TTC) is a rare condition characterized by a sudden temporary weakening of the heart. TTC can mimic acute myocardial infarction and is associated with a minimal release of myocardial biomarkers in the absence of obstructive coronary artery disease. Aims. - To provide an extensive description of patients admitted to hospital for TTC throughout France and to study the management and outcomes of these patients. Methods. - In 14 non-academic hospitals, we collected clinical, electrocardiographic, biological, psychological and therapeutic data in patients with a diagnosis of TTC according to the Mayo Clinic criteria. Results. - Of 117 patients, 91.5% were women, mean±SD age was 71.4±12.1 years and the prevalence of risk factors was high (hypertension: 57.9%, dyslipidaemia: 33.0%, diabetes: 11.5%, obesity: 11.5%). The most common initial symptoms were chest pain (80.5%) and dyspnoea (24.1%). A triggering psychological event was detected in 64.3% of patients. ST-segment elevation was found in 41.7% of patients and T-wave inversion in 71.6%. Anterior leads were most frequently associated with ST-segment elevation, whereas T-wave inversion was more commonly associated with lateral leads, and Q-waves with septal leads. The ratio of peak B-type natriuretic peptide (BNP) or N-terminal prohormone BNP (NT-proBNP) level to peak tro-ponin level was 1.01. No deaths occurred during the hospital phase. After 1 year of follow-up, 3 of 109 (2.8%) patients with available data died, including one cardiovascular death. Rehos-pitalizations occurred in 17.4% of patients: 2.8% due to acute heart failure and 14.7% due to non-cardiovascular causes. There was no recurrence of TTC. Conclusions. — This observational study of TTC included primarily women with atherosclerotic risk factors and mental stress. T-wave inversion was more common than ST-segment elevation. There were few adverse cardiovascular outcomes in these patients after 1 -year follow-up.
机译：摘要背景。 — Takotsubo心肌病（TTC）是一种罕见的疾病，其特征是心脏突然暂时性虚弱。 TTC可以模拟急性心肌梗塞，并且在没有阻塞性冠状动脉疾病的情况下，与心肌生物标志物的最小释放有关。目的-提供对整个法国因TTC住院的患者的广泛描述，并研究这些患者的治疗和转归。方法。 -在14家非学术医院中，我们根据梅奥诊所的标准收集了诊断为TTC的患者的临床，心电图，生物学，心理和治疗数据。结果。 -在117例患者中，女性占91.5％，平均SD年龄为71.4±12.1岁，危险因素的患病率较高（高血压：57.9％，血脂异常：33.0％，糖尿病：11.5％，肥胖：11.5％）。最常见的初始症状是胸痛（80.5％）和呼吸困难（24.1％）。在64.3％的患者中检测到触发性心理事件。 ST段抬高的患者占41.7％，T波倒置的患者占71.6％。前导最常与ST段抬高相关，而T波倒置更常与侧向导联有关，而Q波与间隔导联有关。峰值B型利钠尿肽（BNP）或N端激素激素BNP（NT-proBNP）水平与峰值肌钙蛋白水平之比为1.01。在医院阶段没有死亡发生。随访1年后，有109例具有可用数据的患者中有3例死亡，包括1例心血管死亡。在17.4％的患者中发生了再狭窄：2.8％是由于急性心力衰竭引起的，而14.7％是由于非心血管原因引起的。 TTC没有复发。结论— TTC的这项观察性研究主要包括患有动脉粥样硬化危险因素和精神压力的女性。 T波反演比ST段抬高更为普遍。随访一年后，这些患者的心血管不良反应很少。

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