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首页> 外文期刊>Archives of Biochemistry and Biophysics >Dihydrolipoic acid maintains ubiquinone in the antioxidant active form by two-electron reduction of ubiquinone and one-electron reduction of ubisemiquinone.
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Dihydrolipoic acid maintains ubiquinone in the antioxidant active form by two-electron reduction of ubiquinone and one-electron reduction of ubisemiquinone.

机译：二氢硫辛酸通过泛电子的两电子还原和泛半醌的一电子还原，将泛醌保持在抗氧化剂活性形式中。

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摘要

Dihydrolipoic acid (DHLA) is a constituent of cellular energy metabolism, where it cycles between the oxidized and reduced form. The two thiol residues of DHLA make this biomolecule susceptible to most radical species and prevent Fenton-type reactions by chelating free iron. In this study we present a novel mode of action by which DHLA exerts antioxidant function in combination with coenzyme Q (ubiquinone). DHLA was found to reduce ubiquinone to ubiquinol by the transfer of a pair of electrons, thereby increasing the antioxidant capacity of coenzyme Q in biomembranes. In addition, ubisemiquinone, which was earlier shown to be an active oxygen radical source when existing in the anionic form, is removed from equilibrium by the addition of a single electron from DHLA. The high reactivity of DHLA with this potentially deleterious ubisemiquinone species not only prevents the formation of prooxidants, it also keeps ubiquinone in its antioxidant active form. Experimental data of this study demonstrate a superadditive effect of ubiquinone in combination with DHLA in preventing peroxidation of biomembranes. Copyright 1999 Academic Press.
机译：二氢硫辛酸（DHLA）是细胞能量代谢的组成部分，在氧化和还原形式之间循环。 DHLA的两个硫醇残基使该生物分子对大多数自由基物种敏感，并通过螯合游离铁防止Fenton型反应。在这项研究中，我们提出了一种新的作用方式，DHLA与辅酶Q（泛醌）结合发挥抗氧化功能。发现DHLA通过一对电子的转移将泛醌还原为泛醇，从而提高了生物膜中辅酶Q的抗氧化能力。此外，通过从DHLA中添加单个电子，可以从平衡中除去泛半醌，后者以前以阴离子形式存在时是活性氧自由基源。 DHLA与这种潜在有害的泛半醌种类的高反应性不仅阻止了前氧化剂的形成，还使泛醌保持其抗氧化剂活性形式。这项研究的实验数据表明，泛醌与DHLA联用可防止生物膜的过氧化。版权所有1999，学术出版社。

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