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On the thermotropic and magnetotropic phase behavior of lipid liquid crystals containing magnetic nanoparticles

机译：在正温的magnetotropic阶段脂质液晶包含的行为磁性纳米颗粒

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摘要

The inclusion of superparamagnetic iron oxide nanoparticles (SPIONs) in lipid mesophases is a promising strategy for drug-delivery applications, combining the innate biocompatibility of lipid architectures with SPIONs' response to external magnetic fields. Moreover, the organization of SPIONs within the lipid scaffold can lead to locally enhanced SPIONs concentration and improved magnetic response, which is key to overcome the current limitations of hyperthermic treatments. Here we present a Small-Angle X-ray Scattering (SAXS) structural investigation of the thermotropic and magnetotropic behavior of glyceryl monooleate (GMO)/water mesophases, loaded with hydrophobic SPIONs. We prove that even very low amounts of SPIONs deeply alter the phase behavior and thermotropic properties of the mesophases, promoting a cubic to hexagonal phase transition, which is similarly induced upon application of an Alternating Magnetic Field (AMF). Moreover, in the hexagonal phase SPIONs spontaneously self-assemble within the lipid scaffold into a linear supraparticle. This phase behavior is interpreted in the framework of the Helfrich's theory, which shows that SPIONs affect the mesophase both from a viscoelastic and from a structural standpoint. Finally, the dispersion of these cubic phases into stable magnetic colloidal particles, which retain their liquid crystalline internal structure, is addressed as a promising route towards magneto-responsive drug-delivery systems (DDS).
机译：超顺磁性氧化铁的包容纳米颗粒(SPIONs)在脂质采用有前途的药物传输策略应用程序,结合先天生物相容性的脂质结构SPIONs应对外部磁场。此外,组织内的SPIONs脂质支架可导致局部增强SPIONs浓度和改善磁反应,是克服当前的关键超热状况的治疗方法的局限性。呈现一个小角x射线散射(粉煤灰)向温的和结构性的调查magnetotropic丙三油酸酯的行为(GMO) /水采用含有疏水SPIONs。SPIONs深深改变行为和阶段采用的正温的特性,促进立方六角相变,同样诱导在应用的是哪一个交变磁场(AMF)。六角相SPIONs自发在脂质支架成自组装线性supraparticle。海尔瑞迟的解释的框架理论,它表明SPIONs影响从粘弹性和中间相两种结构的角度来看。这些立方阶段到稳定的磁性胶体粒子,保持他们的液体结晶内部结构,是一种很有前途的解决路线向magneto-responsive药物传输系统(DDS)。

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