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首页> 外文期刊>Nanoscale >Dually responsive gold-iron oxide heterodimers: merging stimuli-responsive surface properties with intrinsic inorganic material features
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Dually responsive gold-iron oxide heterodimers: merging stimuli-responsive surface properties with intrinsic inorganic material features

机译：双重响应金铁氧化形成:合并stimuli-responsive表面性质与内在的无机材料的特性

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摘要

We demonstrate a versatile approach for the preparation of dually responsive smart inorganic hetero-structures (HSs) with the potential for exploitation in nanomedicine. We utilize Au-FexOy dimers as templates for generating smart inorganic HSs with a pH-responsive coating and a thermo-responsive coating attached to iron oxide and gold nanoparticles (NPs), respectively. First, a thiol-modified thermo-responsive (PNIPAAM-co-PEGA) polymer could be selectively attached to the gold domain by ligand exchange. The sequential attachment of a catechol-modified initiator to the iron oxide surface enables the in situ polymerization of a pH-responsive (PDMAEA) polymer. As hereby shown, the presence of the two distinct polymer domains on each NP subdomain enables each side of the HS to be loaded with different agents. Indeed, by a gel electrophoresis experiment we demonstrate the loading of siRNA on the pH-responsive polymer and the loading of Nile Blue dye, used as a drug model molecule, on the thermo-responsive polymer. The smart HSs exhibited good biocompatibility and downregulated GFP production when loaded with anti-GFP siRNA molecules. In addition, an investigation of the magnetic relaxivity times revealed that the high R2 relaxivity values of the HSs suggest their potential as contrast agents in magnetic resonance imaging (MRI) applications.
机译：我们将演示一个通用的方法智能无机制备双重敏感hetero-structures (HSs)的潜力纳米药物的开发。二聚体作为模板生成聪明无机与pH-responsive涂层和高速钢thermo-responsive涂层氧化铁分别和金纳米粒子(NPs)。首先,thiol-modified thermo-responsive(PNIPAAM-co-PEGA)可以选择性的聚合物配位体交换附着在黄金领域。顺序catechol-modified的附件氧化铁表面使引发剂pH-responsive原位聚合(PDMAEA)聚合物。两种不同的聚合物领域的每个NP子域名允许每一方的商品加载不同的代理。电泳实验演示加载的siRNA pH-responsive聚合物尼罗河蓝色染料的加载,用作药物模型在thermo-responsive分子,聚合物。聪明的高速钢表现出良好的生物相容性和表达下调GFP满载时生产anti-GFP核分子。磁relaxivity时报的调查显示的R2 relaxivity高值高速钢显示他们的潜在的对比代理在磁共振成像(MRI)应用程序。

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