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首页> 外文期刊>Archives of medical research >Corrigendum to Effect of α-Linolenic Acid on STZ-Induced Diabetic Retinopathy Indices InVivo. [Archives of Medical Research 44, (2013), 514-520]
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Corrigendum to Effect of α-Linolenic Acid on STZ-Induced Diabetic Retinopathy Indices InVivo. [Archives of Medical Research 44, (2013), 514-520]

机译：关于α-亚麻酸对STZ诱导的糖尿病性视网膜病变指数的影响的更正。 [医学研究档案44，（2013），514-520]

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Background: Pemphigus vulgaris (PV) is an autoimmune disease characterized by acantholysis. PV decreases quality of life and leads to morbidity and mortality. Although the association between PV and otolaryngeal disease has been studied, its effect on olfaction has not been investigated objectively and quantitatively. Methods: Twenty-eight patients with PV and 28 healthy volunteers were included in the study. Lesions were identified via nasal endoscopic examination. Nasal symptoms (itching, obstruction, pain, bleeding, and crusting) were recorded. Volunteers were asked to evaluate their olfactory function via a visual analog scale. The Connecticut Chemosensory Clinical Research Center (CCCRC) olfactory test was performed (butanol threshold test and identification test), and the score was calculated as the mean ± SD. Results: The mean age of the PV group (group 1: 10 male 18 female subjects) was 48.7 ± 8.9 years. The mean age of the control group (group 2: 17 male and 11 female subjects) was 48.0 ± 1.1 years. All nasal symptoms, except itching, were more severe in the PV group (p < 0.05). Nasal lesions were more common in the PV group (p = 0.0001). Evaluation of olfactory function revealed significantly lower scores in the PV group for both the butanol threshold test and the identification testing as well as the CCCRC total score (p = 0.001). PV patients with nasal lesions had significantly more nasal symptoms (p < 0.05). A negative correlation was found between the number of lesions and the olfactory scores in group 1 for the butanol threshold test, identification testing, and the CCCRC total scores, respectively (p = 0.002, p = 0.010, and p = 0.001, respectively). Conclusion: PV causes olfactory dysfunction leading to eventual hyposmia that decreases quality of life. We suggest that olfactory testing be included in PV evaluation for the diagnosis and treatment of hyposmia, when necessary.
机译：背景：寻常型天疱疮（PV）是一种以棘皮松解症为特征的自身免疫性疾病。 PV降低生活质量并导致发病和死亡。尽管已经研究了PV与耳喉疾病之间的关系，但尚未客观，定量地研究其对嗅觉的影响。方法：28名PV患者和28名健康志愿者被纳入研究。通过鼻内镜检查发现病变。记录鼻部症状（发痒，阻塞，疼痛，出血和结cru）。要求志愿者通过视觉模拟量表评估其嗅觉功能。进行了康涅狄格州化学感官临床研究中心（CCCRC）的嗅觉测试（丁醇阈值测试和鉴定测试），并将得分计算为平均值±SD。结果：PV组（组1：10名男性，18名女性）的平均年龄为48.7±8.9岁。对照组（第2组：17名男性和11名女性）的平均年龄为48.0±1.1岁。 PV组除瘙痒外，所有鼻部症状均较严重（p <0.05）。鼻部病变在PV组中更为常见（p = 0.0001）。嗅觉功能的评估显示，丁醇阈值测试和鉴定测试的PV组得分均显着降低，CCCRC总得分也显着降低（p = 0.001）。患有鼻部病变的PV患者的鼻部症状明显更多（p <0.05）。丁醇阈值测试，鉴定测试和CCCRC总得分分别在第1组的皮损数目和嗅觉评分之间呈负相关（分别为p = 0.002，p = 0.010和p = 0.001）。结论：PV引起嗅觉功能障碍，最终导致低渗，降低生活质量。我们建议在必要时将嗅觉测试包括在PV评估中以诊断和治疗低渗症。

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