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首页> 外文期刊>Archives of dermatological research. >Influence of substance-P on cultured sebocytes.
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Influence of substance-P on cultured sebocytes.

机译：P物质对培养的皮脂细胞的影响。

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Acne is a complex, chronic and common skin disorder of pilosebaceous units. Although it is known that exacerbation of acne results from emotional stress, the nature of the association between stress and acne remains unclear. This is due in part to the lack of substantial evidence regarding the participation of cutaneous neurogenic factors in the pathogenesis of acne. Culture of sebocytes provides a new insight into the participation of neuropeptides, notably substance P (SP), in the pathophysiology of acne. To examine the possible involvement of neurogenic factors in the pathogenesis of acne, we used immunohistochemistry and RT-PCR to compare the expression of interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), peroxisome proliferators activated receptors-gamma (PPAR-gamma) on the cultured sebocytes stimulated by SP. IL-1 is primarily proinflammatory cytokines to stimulate the expression of genes associated with inflammation. IL-6 is a pleiotropic cytokine with a wide range of biological activities and regulates inflammation. TNF-alpha is a pleiotropic pro-inflammatory cytokine that exerts multiple biologic effects. PPAR-gamma is a nuclear hormone receptor and plays a unique role in stimulating sebocyte lipogenesis. More numerous immunoreactivity to IL-1, IL-6, TNF-alpha and PPAR-gamma and increased RNA amplification for IL-1, IL-6, TNF-alpha and PPAR-gamma were observed after addition of SP compared with the control. This study reveals that SP is involved in the pathogenesis of acne.
机译：痤疮是一种复杂，慢性和常见的皮脂腺单位皮肤病。尽管众所周知，痤疮的加剧是由于情绪压力引起的，但压力与痤疮之间的联系性质尚不清楚。这部分是由于缺乏有关皮肤神经原性因子参与痤疮发病机理的大量证据。皮脂细胞的培养为痤疮的病理生理中神经肽特别是物质P（SP）的参与提供了新的见识。为了检查神经源性因子可能与痤疮的发病机制有关，我们使用免疫组化和RT-PCR比较了白细胞介素-1（IL-1），白细胞介素-6（IL-6），肿瘤坏死因子-α（过氧化物酶体增殖物（TNF-α）激活了SP刺激的培养皮脂细胞上的受体-γ（PPAR-γ）。 IL-1主要是促炎细胞因子，可刺激与炎症相关的基因的表达。 IL-6是具有多种生物学活性并能调节炎症的多效细胞因子。 TNF-α是一种多效促炎细胞因子，具有多种生物学作用。 PPAR-γ是核激素受体，在刺激皮脂细胞脂肪生成中起独特作用。与对照组相比，在添加SP后，观察到对IL-1，IL-6，TNF-α和PPAR-γ的免疫反应更多，并且IL-1，IL-6，TNF-α和PPAR-γ的RNA扩增增加。这项研究表明SP参与痤疮的发病机理。

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