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首页> 外文期刊>Archives of medical research >Correlation of plasma and synovial fluid adiponectin with knee osteoarthritis severity.
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Correlation of plasma and synovial fluid adiponectin with knee osteoarthritis severity.

机译：血浆和滑液脂联素与膝骨关节炎严重程度的相关性。

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BACKGROUND AND AIMS: Osteoarthritis (OA) is a chronic degenerative joint disorder of the synovial joint characterized by loss of articular cartilage, osteophyte formation, and alterations of subchondral bone. The purposes of this study were to measure adiponectin concentrations in plasma and synovial fluid of patients with knee OA and to analyze the correlation of adiponectin levels with disease severity. METHODS: Seventy six OA patients (mean age 69.8 +/- 1.1 years) and 24 healthy controls (mean age 71.2 +/- 1.5 years) were enrolled in this study. OA grading was performed using the Kellgren-Lawrence (KL) criteria by evaluating x-ray changes observed in anteroposterior knee radiography. Adiponectin levels in plasma and synovial fluid were determined by commercial enzyme-linked immunosorbent assay. RESULTS: Plasma levels of adiponectin were higher in OA patients compared to healthy individuals, but the difference did not reach statistical significance (2428.0 +/- 245.1 vs. 2030.3 +/- 399.4 ng/mL, p = 0.4). Adiponectin levels in plasma were remarkably higher with regard to paired synovial fluid (2428.0 +/- 245.1 vs. 301.3 +/- 44.9 ng/mL, p <0.001). Additionally, adiponectin concentrations in plasma and synovial fluid showed significant inverse correlation with disease severity evaluated by KL grading criteria (r = -0.68, p <0.001 and r = -0.47, p <0.001, respectively). Further analysis showed that plasma adiponectin levels positively correlated with synovial fluid adiponectin levels (r = 0.71, p <0.001). CONCLUSIONS: Adiponectin levels in both plasma and synovial fluid decreased significantly as the severity of OA increased. These findings suggested that adiponectin may play a protective role in OA. More studies are warranted to gain insight into the potential utility of adiponectin as a biochemical determinant of disease progression and prognosis.
机译：背景与目的：骨关节炎（OA）是一种滑膜关节的慢性退行性关节疾病，其特征是关节软骨丧失，骨赘形成和软骨下骨改变。这项研究的目的是测量膝骨关节炎患者血浆和滑液中脂联素的浓度，并分析脂联素水平与疾病严重程度的关系。方法：该研究纳入了76名OA患者（平均年龄69.8 +/- 1.1岁）和24名健康对照（平均年龄71.2 +/- 1.5岁）。使用Kellgren-Lawrence（KL）标准通过评估在前后膝关节X线照相中观察到的X射线变化来进行OA分级。通过商业酶联免疫吸附测定法测定血浆和滑液中的脂联素水平。结果：与健康个体相比，OA患者的血浆脂联素水平更高，但差异没有统计学意义（2428.0 +/- 245.1 vs. 2030.3 +/- 399.4 ng / mL，p = 0.4）。就成对的滑液而言，血浆中的脂联素水平明显更高（2428.0 +/- 245.1与301.3 +/- 44.9 ng / mL，p <0.001）。此外，血浆和滑液中脂联素浓度与通过KL分级标准评估的疾病严重程度呈显着负相关（分别为r = -0.68，p <0.001和r = -0.47，p <0.001）。进一步的分析表明，血浆脂联素水平与滑液脂联素水平呈正相关（r = 0.71，p <0.001）。结论：随着OA严重程度的增加，血浆和滑液中脂联素的水平显着降低。这些发现表明脂联素可能在OA中起保护作用。有必要进行更多的研究，以深入了解脂联素作为疾病进展和预后的生化决定因素的潜在用途。

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