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首页> 外文期刊>Archives of medical research >Extracellular matrix metalloproteinase inducer (EMMPRIN), acute myocardial infarction and the Kounis syndrome.
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Extracellular matrix metalloproteinase inducer (EMMPRIN), acute myocardial infarction and the Kounis syndrome.

机译:细胞外基质金属蛋白酶诱导剂(EMMPRIN),急性心肌梗塞和Kounis综合征。

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摘要

In their very important paper published in Archives of Medical Research (1), the authors found that EMMPRIN and matrix metalloproteinases (MMPs) such as MMP-2 and MMP-9 expression was increased in the area surrounding the infarct zone in human acute myocardial infarction (AMI) and this may play a critical role in left ventricular remodeling. However, they have omitted to comment on the role of MMPs in degrading the fibrous cap of vulnerable atheroma-tous plaque, which is the primary step in the development of coronary thrombosis. Elevated plasma levels of different MMPs have been found in patients with acute myocardial infarction and are associated with severe coronary stenosis and cardiovascular mortality (2).
机译:在发表于《医学研究档案》(Archives of Medical Research)的非常重要的论文中(1),作者发现EMMPRIN和基质金属蛋白酶(MMPs)(例如MMP-2和MMP-9)的表达在急性心肌梗塞梗塞区域周围的区域增加了(AMI),这可能在左心室重塑中起关键作用。但是,他们没有评论MMP在降解易损动脉粥样斑块的纤维帽中的作用,这是发展冠状动脉血栓形成的第一步。在急性心肌梗死患者中发现不同MMP的血浆水平升高,并与严重的冠状动脉狭窄和心血管疾病的死亡率相关(2)。

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