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首页> 外文期刊>Archives of medical research >Combined hyperbaric oxygen and hypothermia treatment on oxidative stress parameters after spinal cord injury: an experimental study.
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Combined hyperbaric oxygen and hypothermia treatment on oxidative stress parameters after spinal cord injury: an experimental study.

机译：高压氧联合低温治疗脊髓损伤后氧化应激参数的实验研究。

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BACKGROUND AND AIMS: We undertook this study to investigate the possible beneficial effects of combined hypothermia and hyperbaric oxygen (HBO) treatment in comparison with methylprednisolone in experimental spinal cord injury (SCI). METHODS: Forty eight male Wistar albino rats (200-250 g) were randomized into six groups; A (normothermic control group; only laminectomy), B (normothermic trauma group; laminectomy + spinal trauma), C (normothermic methylprednisolone group; laminectomy + spinal trauma + methylprednisolone treated), D (hypothermia group; laminectomy + spinal trauma + hypothermia treated); E (HBO group; laminectomy + spinal trauma + HBO therapy), F (hypothermia and HBO group; laminectomy + spinal trauma + hypothermia and HBO treated) each containing eight rats. Neurological assessments were performed 24 h after trauma and spinal cord tissue samples had been harvested for both biochemical and histopathological evaluation. RESULTS: After SCI, tissue malondialdehyde (MDA) level of the control group was measured increased, and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) enzyme activities were measured decreased. In group F, it was also shown that MDA level elevation had been prevented, and group F has increased the antioxidant enzyme activities than the other experimental groups C, D, E (p <0.05). CONCLUSIONS: We concluded that the use of combined hypothermia and HBO treatment might have potential benefits in spinal cord tissue on secondary damage.
机译：背景与目的：我们进行了这项研究，以调查低温和高压氧（HBO）联合治疗与甲基强的松龙在实验性脊髓损伤（SCI）中的可能的有益作用。方法：将48只雄性Wistar白化病大鼠（200-250 g）随机分为六组; A（常温对照组;仅椎板切除术），B（常温创伤组;椎板切除术+脊柱创伤），C（常温甲基泼尼松龙组;椎板切除术+脊柱创伤+甲基泼尼松龙治疗），D（体温过低组;椎板切除术+脊柱创伤+体温过低治疗） ; E（HBO组;椎板切除术+脊柱创伤+ HBO治疗），F（低体温和HBO组;椎板切除术+脊柱创伤+体温过低和HBO治疗）每组八只大鼠。在创伤和脊髓组织样品采集后24小时进行神经学评估，以进行生化和组织病理学评估。结果：SCI后，对照组的组织丙二醛（MDA）水平升高，而超氧化物歧化酶（SOD），谷胱甘肽过氧化物酶（GSH-Px）和过氧化氢酶（CAT）活性降低。在F组中，还表明，与其他实验组C，D，E相比，已防止了MDA水平的升高，并且F组增加了抗氧化酶的活性（p ＜0.05）。结论：我们得出结论，低温联合HBO治疗可能对继发性损伤的脊髓组织具有潜在的益处。

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