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首页> 外文期刊>Archives of medical research >Glutathione S-transferase M1 gene polymorphism and gastric cancer risk: an updated analysis.
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Glutathione S-transferase M1 gene polymorphism and gastric cancer risk: an updated analysis.

机译：谷胱甘肽S-转移酶M1基因多态性与胃癌风险：最新分析。

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BACKGROUND AND AIMS: Studies investigating the association between glutathione S-transferase M1 (GSTM1) gene polymorphism and gastric cancer (GC) risk have reported conflicting results. In order to clarify the effect of GSTM1 genotype on the GC risk, we performed an updated meta-analysis of published case-control and cohort studies to better compare results between studies. METHODS: Published literature from PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) were retrieved, and the literature search was updated on June 15, 2010. 49 studies with 7746 cases of GC and 13,230 controls were selected. A fixed- or random-effects model was used to calculate pooled effect estimates depending on statistical heterogeneity. RESULTS: The combined analyses showed that there was a significant difference in genotype distribution between GC cases and controls among Asians, but not among Caucasians. Stratified analyses according to control sources also showed the positive association between GSTM1 null genotype and increased risk of GC. However, smoking and Helicobacter pylori infection did not modify the association between this polymorphism and GC susceptibility (p = 0.56 and 0.31, respectively). When stratifying by the location, Lauren's classification, and histological differentiation of GC, we observed no statistically significant differences in genotype distribution. A strong correlation between increased GC risk and the combined GSTM1 and GSTT1 null genotype was observed. CONCLUSIONS: This meta-analysis demonstrated that the GSTM1 gene polymorphism might be a risk factor for GC among Asians (especially, in some Eastern countries). Smoking, Helicobacter pylori infection status did not modify the association between GSTM1 null genotype and GC risk.
机译：背景与目的：研究谷胱甘肽S-转移酶M1（GSTM1）基因多态性与胃癌（GC）风险之间关系的研究报告了相互矛盾的结果。为了阐明GSTM1基因型对GC风险的影响，我们对已发表的病例对照研究和队列研究进行了更新的荟萃分析，以更好地比较研究之间的结果。方法：检索来自PubMed，EMBASE和中国国家知识基础设施（CNKI）的已发表文献，并于2010年6月15日更新文献检索。选择了49篇涉及7746例GC和13230例对照的研究。固定或随机效应模型用于根据统计异质性来计算合并效应估计。结果：综合分析表明，GC病例与对照组之间的基因型分布在亚洲人之间存在显着差异，而在白种人之间则没有。根据对照来源进行的分层分析还显示，GSTM1无效基因型与GC风险增加之间呈正相关。但是，吸烟和幽门螺杆菌感染并未改变这种多态性与GC敏感性之间的关联（分别为p = 0.56和0.31）。当按位置，Lauren的分类和GC的组织学分类进行分层时，我们观察到基因型分布没有统计学上的显着差异。观察到增加的GC风险与合并的GSTM1和GSTT1无效基因型之间的密切相关性。结论：这项荟萃分析表明，GSTM1基因多态性可能是亚洲人（尤其是某些东方国家）发生GC的危险因素。吸烟，幽门螺杆菌感染状态并未改变GSTM1无效基因型与GC风险之间的关联。

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