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首页> 外文期刊>Archives of dermatological research. >Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells.
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Polyhydroxylated fatty alcohols derived from avocado suppress inflammatory response and provide non-sunscreen protection against UV-induced damage in skin cells.

机译：源自鳄梨的多羟基化脂肪醇可抑制炎症反应，并提供非防晒保护，防止紫外线引起的皮肤细胞损伤。

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摘要

Exposing skin to ultraviolet (UV) radiation contributes to photoaging and to the development of skin cancer by DNA lesions and triggering inflammatory and other harmful cellular cascades. The present study tested the ability of unique lipid molecules, polyhydroxylated fatty alcohols (PFA), extracted from avocado, to reduce UVB-induced damage and inflammation in skin. Introducing PFA to keratinocytes prior to their exposure to UVB exerted a protective effect, increasing cell viability, decreasing the secretion of IL-6 and PGE(2), and enhancing DNA repair. In human skin explants, treating with PFA reduced significantly UV-induced cellular damage. These results support the idea that PFA can play an important role as a photo-protective agent in UV-induced skin damage.
机译：使皮肤暴露于紫外线（UV）会导致光老化，并通过DNA损伤和引发炎症性及其他有害细胞级联反应而发展为皮肤癌。本研究测试了从鳄梨中提取的独特脂质分子多羟基化脂肪醇（PFA）减少UVB诱导的皮肤损伤和炎症的能力。在暴露于UVB之前将PFA引入角质形成细胞可起到保护作用，增加细胞活力，减少IL-6和PGE（2）的分泌，并增强DNA修复。在人的皮肤外植体中，用PFA处理可显着减少紫外线引起的细胞损伤。这些结果支持了PFA在紫外线诱导的皮肤损伤中作为光保护剂发挥重要作用的想法。

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