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首页> 外文期刊>Archives of dermatological research. >Phytosphingosine-1-phosphate represses the hydrogen peroxide-induced activation of c-Jun N-terminal kinase in human dermal fibroblasts through the phosphatidylinositol 3-kinase/Akt pathway
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Phytosphingosine-1-phosphate represses the hydrogen peroxide-induced activation of c-Jun N-terminal kinase in human dermal fibroblasts through the phosphatidylinositol 3-kinase/Akt pathway

机译：植物鞘氨醇-1-磷酸通过磷脂酰肌醇3-激酶/ Akt途径抑制过氧化氢诱导的人皮肤成纤维细胞中c-Jun N末端激酶的活化

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摘要

Dermal fibroblasts are differentiated mesenchymal cells that regulate the extracellular matrix through the production of dermis components. Dermal fibroblasts can be damaged by reactive oxygen species induced by ultraviolet rays and chemicals. In addition to its effects on the dermis, oxidative stress poses a major threat to organisms and is believed to play an essential role in many disease processes. In this study, we show that human dermal fibroblasts (HDFs) express sphingosine-1-phosphate (S1P) receptors S1P1, S1P2, and S1P3. In addition, cell viability of HDFs is increased by phytosphingosine-1-phosphate (PhS1P) via regulation of the Jun N-terminal kinase (JNK)/Akt pathway. Interestingly, regulation of the JNK/Akt pathway by PhS1P attenuated H 2O 2-induced cell growth arrest. Together, our data indicate that PhS1P attenuates H 2O 2-induced growth arrest through regulation of the signal molecules Akt and JNK, and suggest that PhS1P may have value as an anti-aging material in cosmetics and medicine.
机译：真皮成纤维细胞是分化的间充质细胞，通过真皮成分的产生来调节细胞外基质。皮肤成纤维细胞会受到紫外线和化学物质诱导产生的活性氧的破坏。氧化应激除了对真皮产生影响外，还对生物体构成了重大威胁，并被认为在许多疾病过程中起着至关重要的作用。在这项研究中，我们表明人类皮肤成纤维细胞（HDF）表达1磷酸鞘氨醇（S1P）受体S1P1，S1P2和S1P3。此外，通过调节Jun N-末端激酶（JNK）/ Akt途径，植物神经鞘氨醇-1-磷酸（PhS1P）可提高HDF的细胞活力。有趣的是，PhS1P对JNK / Akt通路的调节减弱了H 2O 2诱导的细胞生长停滞。总之，我们的数据表明PhS1P通过调节信号分子Akt和JNK减弱H 2O 2诱导的生长停滞，并表明PhS1P在化妆品和药物中可能具有抗衰老的作用。

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