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首页> 外文期刊>Archives of disease in childhood >BK virus DNA in CSF of immunocompetent and immunocompromised patients.
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BK virus DNA in CSF of immunocompetent and immunocompromised patients.

机译：免疫能力强和免疫功能低下患者脑脊液中的BK病毒DNA。

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摘要

AIM: To investigate the possible aetiological role of BK and JC viruses in immunocompetent and immunocompromised children with suspected encephalitis and meningoencephalitis. METHODS: The polymerase chain reaction and microplate hybridisation method was employed for the detection of polyomavirus DNA in 266 CSF specimens collected from immunocompetent and immunocompromised patients. RESULTS: BK virus DNA was detected in three (2.1%) CSF samples taken from patients aged 2-5 years; two were patients with acute lymphocytic leukaemia without overt neurological symptoms, the other was a patient with suspected encephalitis. BK virus DNA was also detected in two (1.6%) CSF samples taken from older children in the age range 10-16 years; both children had suspected encephalitis. JC virus DNA was not found in any CSF sample from either age group. CONCLUSIONS: Detection of BK virus in the CSF of immunocompromised and immunocompetent patients with suspected neurological disease suggests that this virus may have hada pathogenic role in the aetiology of this condition.
机译：目的：探讨BK和JC病毒在怀疑患有脑炎和脑膜脑炎的免疫能力强和免疫功能低下的儿童中可能的病原学作用。方法：采用聚合酶链反应和微孔板杂交法检测了266例从有免疫能力和免疫功能低下的患者采集的脑脊液标本中的多瘤病毒DNA。结果：从2-5岁患者中采集的三份（2.1％）脑脊液样本中检测到BK病毒DNA;两名是没有明显神经系统症状的急性淋巴细胞白血病患者，另一名是疑似脑炎患者。在两个10至16岁年龄较大的儿童的脑脊液样本中也检测到BK病毒DNA。两个孩子都怀疑有脑炎。在任一年龄组的任何CSF样本中均未发现JC病毒DNA。结论：在免疫功能低下和具有免疫能力的可疑神经系统疾病患者的脑脊液中检测到BK病毒，表明该病毒可能在此病的病因中具有致病作用。

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