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首页> 外文期刊>Archives of dermatological research. >Ubiquitination in host immune response to human papillomavirus infection.
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Ubiquitination in host immune response to human papillomavirus infection.

机译：宿主对人乳头瘤病毒感染的免疫反应中的泛素化。

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摘要

Human papillomavirus (HPV) infection with low-risk or high-risk subtypes is very common. Infection with HPVs is often a major causative factor for the development of cutaneous benign lesions, cervical cancer, and a number of other tumors. The mechanisms of host immunity to prevent and control HPV infection still remain unclear. The importance of ubiquitination (or ubiquitylation) as an intracellular proteasomal-mediated protein degradation pathway, and as an important modulator for the regulation of many fundamental cellular processes has been valued over the last decade. Although the molecular and cellular mechanisms are not completely established, the critical role of ubiquitination in host immune response to HPV infection has become increasingly apparent. This review summarizes current knowledge on the possible role that ubiquitination plays in regulating the host immune response during HPV infection. Targeting the components of the ubiquitin system might offer potential therapeutic strategies for HPV-related diseases in the future.
机译：低风险或高风险亚型的人乳头瘤病毒（HPV）感染非常常见。 HPV感染通常是导致皮肤良性病变，子宫颈癌和许多其他肿瘤发展的主要诱因。预防和控制HPV感染的宿主免疫机制仍不清楚。在过去的十年中，泛素化（或泛素化）作为细胞内蛋白酶介导的蛋白质降解途径以及作为调节许多基本细胞过程的重要调节剂的重要性已得到重视。尽管分子和细胞机制尚未完全确立，但泛素化在宿主对HPV感染的免疫反应中的关键作用已变得越来越明显。这篇综述总结了有关泛素化在HPV感染过程中调节宿主免疫反应中可能发挥的作用的最新知识。靶向泛素系统的成分可能会在将来为HPV相关疾病提供潜在的治疗策略。

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