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首页> 外文期刊>Archives of dermatological research. >Plucking during telogen induces apoptosis in the lower part of hair follicles.
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Plucking during telogen induces apoptosis in the lower part of hair follicles.

机译：毛发生长的过程中采摘会诱导毛囊下部的细胞凋亡。

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Highly synchronized anagen development is achieved by depilation, which contrasts with spontaneous anagen development. The precise mechanism responsible for plucking-induced synchronization has not been explained. Plucking appears to mechanically injure or wound the follicle. We hypothesized that the injured hair follicle cells are removed by apoptosis, with an associated induction of synchronized anagen development. Female C57 BL/6 mice in which all the hair follicles of the back skin were in telogen were induced to enter anagen by depilation. Skin specimens from the back at 0 to 72 h after plucking were examined, and TUNEL staining and electrophoresis of isolated DNA were applied to substantiate the presence of apoptosis. Simultaneously, cell proliferation was also examined by bromodeoxyuridine (BrdU) incorporation. All methods of analysis revealed that plucking induced apoptosis of hair follicle cells in the dermal remnant, and there was a subsequent associated proliferative response that resulted in a highly synchronized anagen phase. From 12 to 36 h after plucking, hair follicle cells with weakly BrdU-positive nuclei were detected around the holes in the lower part of the follicle, which were induced by plucking. At 48 and 72 h, many cells with BrdU-positive nuclei were seen in the entire follicle, mainly in the bulb, as well as in the epidermis. Cell proliferation and apoptosis appeared to occur simultaneously after plucking. These findings mirror the events noted during the development of other organs in which the coordination of cell proliferation and apoptosis is essential for orderly restructuring events.
机译：通过脱毛可以实现高度同步的生长期发育，这与自发的生长期发育形成鲜明对比。尚未解释造成拔除同步的精确机制。采摘似乎机械损伤或缠绕了卵泡。我们假设受伤的毛囊细胞被细胞凋亡去除，同时伴随着毛发生长过程的诱导。通过脱毛使雌性C57 BL / 6小鼠（其中背部皮肤的所有毛囊都处于毛发生长期）进入毛发生长初期。拔除后0到72 h，检查背部皮肤样本，并进行TUNEL染色和分离的DNA电泳，以证实细胞凋亡的存在。同时，还通过掺入溴脱氧尿苷（BrdU）检查了细胞增殖。所有分析方法均表明，拔毛可诱导真皮残余物中毛囊细胞凋亡，并且随后发生了相关的增殖反应，从而导致毛发生长期高度同步。拔毛后12到36 h，在毛囊下部孔周围检测到BrdU阳性核弱的毛囊细胞，这些毛囊细胞是通过拔毛诱导的。在第48和72小时，在整个卵泡中（主要在鳞茎和表皮中）看到许多具有BrdU阳性核的细胞。拔毛后细胞增殖和凋亡似乎同时发生。这些发现反映了在其他器官发育过程中注意到的事件，其中细胞增殖和凋亡的协调对于有序重组事件至关重要。

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