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首页> 外文期刊>Archives of disease in childhood >Breast feeding and allergic diseases in infants-a prospective birth cohort study.
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Breast feeding and allergic diseases in infants-a prospective birth cohort study.

机译：婴儿的母乳喂养和过敏性疾病-前瞻性队列研究。

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AIMS: To investigate the effect of breast feeding on allergic disease in infants up to 2 years of age. METHODS: A birth cohort of 4089 infants was followed prospectively in Stockholm, Sweden. Information about various exposures was obtained by parental questionnaires when the infants were 2 months old, and about allergic symptoms and feeding at 1 and 2 years of age. Duration of exclusive and partial breast feeding was assessed separately. Symptom related definitions of various allergic diseases were used. Odds ratios (OR) and 95% confidence intervals (CI) were estimated in a multiple logistic regression model. Adjustments were made for potential confounders. RESULTS: Children exclusively breast fed during four months or more exhibited less asthma (7.7% v 12%, OR(adj) = 0.7, 95% CI 0.5 to 0.8), less atopic dermatitis (24% v 27%, OR(adj) = 0.8, 95% CI 0.7 to 1.0), and less suspected allergic rhinitis (6.5% v 9%, OR(adj) = 0.7, 95% CI 0.5 to 1.0) by 2 years of age. There was a significant risk reduction for asthma related to partial breast feeding during six months or more (OR(adj) = 0.7, 95% CI 0.5 to 0.9). Three or more of five possible allergic disorders-asthma, suspected allergic rhinitis, atopic dermatitis, food allergy related symptoms, and suspected allergic respiratory symptoms after exposure to pets or pollen-were found in 6.5% of the children. Exclusive breast feeding prevented children from having multiple allergic disease (OR(adj) = 0.7, 95% CI 0.5 to 0.9) during the first two years of life. CONCLUSION: Exclusive breast feeding seems to have a preventive effect on the early development of allergic disease-that is, asthma, atopic dermatitis, and suspected allergic rhinitis, up to 2 years of age. This protective effect was also evident for multiple allergic disease.
机译：目的：探讨母乳喂养对2岁以下婴儿过敏性疾病的影响。方法：前瞻性追踪瑞典斯德哥尔摩的4089名婴儿的出生队列。婴儿在两个月大时通过父母问卷获得了各种接触的信息，以及在1岁和2岁时出现的过敏症状和喂养情况。分别评估纯母乳喂养和部分母乳喂养的持续时间。使用了各种过敏性疾病的症状相关定义。在多元逻辑回归模型中估算了赔率（OR）和95％置信区间（CI）。针对潜在的混杂因素进行了调整。结果：四个月或以上纯母乳喂养的儿童哮喘较少（7.7％v 12％，OR（adj）= 0.7，95％CI 0.5至0.8），特应性皮炎较少（24％v 27％，OR（adj） = 2岁时，其= 0.8，95％CI为0.7至1.0），可疑变应性鼻炎的可能性较低（6.5％v 9％，OR（adj）= 0.7，95％CI为0.5至1.0）。在六个月或更长时间内，与部分母乳喂养相关的哮喘风险显着降低（OR（adj）= 0.7，95％CI 0.5至0.9）。在6.5％的儿童中，发现了五种可能的过敏性疾病中的三种或三种以上-哮喘，疑似过敏性鼻炎，特应性皮炎，食物过敏相关症状以及疑似暴露于宠物或花粉后的过敏性呼吸道症状。纯母乳喂养可防止儿童在出生后的头两年患有多种过敏性疾病（OR（adj）= 0.7，95％CI 0.5至0.9）。结论：纯母乳喂养似乎对过敏性疾病的早期发展具有预防作用，即2岁以下的哮喘，特应性皮炎和疑似过敏性鼻炎。这种保护作用对于多种过敏性疾病也很明显。

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