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首页> 外文期刊>Archives of dermatological research. >Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with decreased risk for basal cell carcinoma.
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Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with decreased risk for basal cell carcinoma.

机译：血管紧张素转换酶基因插入/缺失多态性与基底细胞癌风险降低的相关性。

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The incidence of basal cell carcinoma (BCC) is significantly reduced in individuals treated with inhibitors of angiotensin I-converting enzyme (ACE) that produces angiotensin II. The objective of this study was to investigate the possible association of a functional polymorphism in the ACE gene, which affects its transcription, with risk for BCC. In DNA samples of 92 patients with BCC and 103 healthy controls of Greek origin and comparable age and gender, we studied the ACE gene insertion/deletion (I/D) polymorphism. Fisher's exact test was used for comparison of allele and genotype frequencies between the control and patients' groups. The detected low expression I allele frequency in the group of BCC patients was significantly decreased compared to controls (15.8 vs. 31.1 %, respectively; P = 0.001). ID heterozygotes exhibited 3.06 times lower BCC risk, compared with DD homozygotes (P = 0.001; OR = 0.327, 95 % CI = 0.174-0.615). The protective role of I allele was particularly prominent in women (P = 0.007, OR = 0.299, 95 % CI = 0.125-0.716), while for men it exhibited a marginal level (P = 0.041). These findings indicate that the low expression ACE I allele carriers have a decreased risk for BCC. The protective effect of the ID genotype against BCC may be explained by a possible underlying mechanism involving the effect of produced angiotensin II levels on its receptors due to putatively different binding affinity.
机译：在使用产生血管紧张素II的血管紧张素I转换酶（ACE）抑制剂治疗的个体中，基底细胞癌（BCC）的发生率显着降低。这项研究的目的是调查ACE基因中功能多态性可能会影响其转录，并将其与BCC风险相关联。在92名BCC患者和103名希腊血统以及年龄和性别相仿的健康对照患者的DNA样本中，我们研究了ACE基因插入/缺失（I / D）多态性。 Fisher的精确检验用于比较对照组和患者组之间的等位基因和基因型频率。与对照组相比，在BCC患者组中检测到的低表达I等位基因频率显着降低（分别为15.8和31.1％; P = 0.001）。与DD纯合子相比，ID杂合子的BCC风险低3.06倍（P = 0.001; OR = 0.327，95％CI = 0.174-0.615）。 I等位基因的保护作用在女性中尤为突出（P = 0.007，OR = 0.299，95％CI = 0.125-0.716），而在男性中则表现出临界水平（P = 0.041）。这些发现表明，低表达ACE I等位基因携带者具有降低的BCC风险。 ID基因型对BCC的保护作用可以通过可能的潜在机制来解释，该机制涉及由于推测的结合亲和力而产生的血管紧张素II水平对其受体的影响。

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