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首页> 外文期刊>Archives of dermatological research. >Increased cutaneous oxygen availability by topical application of hydrogen peroxide cream enhances the photodynamic reaction to topical 5-aminolevulinic acid-methyl ester.
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Increased cutaneous oxygen availability by topical application of hydrogen peroxide cream enhances the photodynamic reaction to topical 5-aminolevulinic acid-methyl ester.

机译：通过局部施用过氧化氢乳膏增加的皮肤氧可利用性增强了对局部5-氨基乙酰丙酸甲酯的光动力反应。

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Topical 5-aminolevulinic acid (ALA) and methyl aminolevulinate (MAL) photodynamic therapy (PDT) of skin lesions is an accepted treatment for skin tumours but success rates need improvement. The effectiveness of PDT is influenced by availability of oxygen. The aim of this study was to demonstrate, in normal skin, whether a decrease in skin oxygen tension reduces the photodynamic reaction (PDR); and whether the addition of topical hydrogen peroxide can reverse the effect. Topical MAL and red light were administered to the inner forearms of 40 healthy volunteers. Skin oxygen availability was lowered during the illumination phase of the PDT, by applying blanching pressure with a plastic slide. Topical hydrogen peroxide was applied under the pressure slide, immediately prior to illumination, to reverse the effect. Erythema was assessed by naked eye and laser Doppler perfusion imaging (LDPI), at baseline and at 1, 5, 24 and 48 h following illumination. Decreasing oxygen availability by pressure altered the PDR with a larger number of subjects (17.5%) not demonstrating any visible erythema at any time point after plastic slide pressure compared to a PDR Control site (7.5%). The addition of topical hydrogen peroxide during pressure application, restored the number of subjects showing no visible erythema compared to that of PDR Control. LDPI data showed that there was a decrease in mean perfusion after plastic slide pressure when comparing the change from baseline to 24 h (P < 0.05) with the PDR Control. The addition of hydrogen peroxide not only restored but also increased the mean perfusion compared to that of PDR Control when comparing the change from baseline to 5 h and the change from baseline to 24 h (P < 0.001). Increasing oxygen availability increased the PDR in normal skin. The possibility that addition of topical hydrogen peroxide to PDT protocols for non-melanoma skin cancer may increase reactivity and, thus, be relevant for outcomes warrants further study.
机译：皮肤病灶的局部5-氨基乙酰丙酸（ALA）和氨基乙酰丙酸甲酯（MAL）光动力疗法（PDT）是皮肤肿瘤的公认疗法，但成功率有待提高。 PDT的有效性受氧气供应量的影响。这项研究的目的是证明在正常的皮肤中，皮肤氧张力的降低是否会降低光动力反应（PDR）。以及是否添加局部过氧化氢可以逆转这种作用。对40名健康志愿者的前臂内侧进行局部MAL和红光照射。在PDT的照明阶段，通过使用塑料载玻片施加烫切压力降低了皮肤的氧气利用率。紧接在照明之前，将局部过氧化氢施加在压力滑片下以逆转效果。在基线以及照明后1、5、24和48小时，通过肉眼和激光多普勒灌注成像（LDPI）评估红斑。与PDR对照部位（7.5％）相比，在通过塑料滑动压力后的任何时间点，通过压力降低氧气供应量都会改变PDR，在较大的受试者中（17.5％）没有显示任何可见的红斑。与PDR对照相比，在加压过程中添加局部过氧化氢可恢复无可见红斑的受试者人数。 LDPI数据显示，与PDR对照比较从基线到24小时的变化（P <0.05）后，塑料滑动压力后的平均灌注减少。当比较从基线到5小时的变化和从基线到24小时的变化时，与PDR对照相比，过氧化氢的添加不仅可以恢复，而且可以增加平均灌注（P <0.001）。氧气供应的增加会增加正常皮肤的PDR。在非黑色素瘤皮肤癌的PDT方案中添加局部过氧化氢可能会增加反应性，因此与结果相关，这一可能性值得进一步研究。

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