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首页> 外文期刊>Archives of dermatological research. >Evaluation of the antihistamine effects of olopatadine, cetirizine and fexofenadine during a 24 h period: a double-blind, randomized, crossover, placebo-controlled comparison in skin responses induced by histamine iontophoresis.
【24h】

Evaluation of the antihistamine effects of olopatadine, cetirizine and fexofenadine during a 24 h period: a double-blind, randomized, crossover, placebo-controlled comparison in skin responses induced by histamine iontophoresis.

机译：评估24小时内奥洛他定，西替利嗪和非索非那定的抗组胺作用：由组胺离子电渗疗法诱导的皮肤反应的双盲，随机，交叉，安慰剂对照比较。

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摘要

Potency of the antihistamine effects of olopatadine, cetirizine and fexofenadine in standard-dose application were compared from 11.5 to 24 h after application. The test was designed in a double-blind, randomized, crossover, placebo-controlled study of ten healthy volunteers on histamine-induced flare and wheal response using an iontophoresis technique. The suppressive effect of olopatadine on the wheals induced by a 0.1-mA histamine iontophoresis lasted for 24 h after dosing. Fexofenadine administered using the same regimen was the least effective among three drugs tested. Suppression of the wheal response by cetirizine, taken once-daily, decreased with time. Olopatadine completely suppressed even the wheal response induced by a 0.2-mA histamine iontophoresis, although fexofenadine and cetirizine were less effective on the wheals induced by the same histamine challenge. There were no significant differences in subjective drowsiness and objective cognitive function between drug- and placebo-treated subjects. These results demonstrate that olopatadine is the most potent antihistamine among the three H(1)-blockers when administered in a standard dosage.
机译：在施用后11.5至24小时，比较了奥洛他定，西替利嗪和非索非那定在标准剂量下的抗组胺作用的效力。该测试是通过使用离子电渗技术对十名健康志愿者进行的组胺诱导的耀斑和风疹反应的双盲，随机，交叉，安慰剂对照研究而设计的。剂量给药后，奥洛他定对0.1-mA组胺离子电渗疗法诱导的风团的抑制作用持续24小时。使用相同方案的非索非那定在三种测试药物中效果最低。每天服用一次西替利嗪抑制人的呼吸反应，随时间而减少。尽管非索非那定和西替利嗪在相同的组胺激发下产生的鲸鱼效果较差，但奥洛他定甚至完全抑制了由0.2 mA组胺离子电渗疗法引起的回缩反应。在药物治疗和安慰剂治疗的受试者之间，主观嗜睡和客观认知功能无显着差异。这些结果表明，以标准剂量给药时，奥洛他定是三种H（1）受体阻滞剂中最有效的抗组胺药。

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