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首页> 外文期刊>Archives of dermatological research. >A case of non-selective phagocytosis of hemosiderin and melanin of dermal histiocytes in stasis dermatitis.
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A case of non-selective phagocytosis of hemosiderin and melanin of dermal histiocytes in stasis dermatitis.

机译：停滞性皮炎中真皮组织细胞含铁血黄素和黑色素非选择性吞噬的一例。

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摘要

A case study was undertaken to determine whether or not the same dermal histiocytes could phagocytose both melanin and hemosiderin simultaneously. A biopsy specimen was taken from a pigmented lesion of the lower leg of a 57-year-old woman with stasis dermatitis. The specimen was processed for histology, conventional transmission electron microscopy and electron-probe X-ray microanalysis. Histologically, numerous histiocytes with their cytoplasm packed with either Prussian blue-positive granules or Fontana-Masson-positive granules were distributed almost equally in the dermis. Electron microscopically, the dermis had many histiocytes with their cytoplasm containing solitary or compound electron-dense substances. The electron-dense substances were classified into three types according to their degree of electron density. By electron-probe X-ray microanalysis, these electron-dense substances were classified into iron-containing and non-iron-containing substances. Both substances were seen in the cytoplasmof the same histiocytes and even in the same compound electron-dense substance. The former were siderosomes and the latter were probably melanosomes. These results show that the same dermal histiocytes probably phagocytose non-selectively both hemosiderin and melanin granules.
机译：进行了案例研究，以确定相同的真皮组织细胞是否可以同时吞噬黑色素和含铁血黄素。活检标本取自一名患有瘀滞性皮炎的57岁妇女的小腿色素沉着病变。对标本进行组织学，常规透射电子显微镜和电子探针X射线显微分析。从组织学上看，许多细胞质的细胞质充满了普鲁士蓝阳性颗粒或丰塔纳-马森阳性颗粒，几乎分布在真皮中。电子显微镜下，真皮中有许多组织细胞，其细胞质中含有孤立的或复合的电子致密物质。根据电子密度，将电子致密物质分为三种类型。通过电子探针X射线显微分析，将这些电子致密物质分为含铁物质和不含铁物质。两种物质都出现在相同组织细胞的细胞质中，甚至出现在相同的复合电子致密物质中。前者是铁体，而后者可能是黑素体。这些结果表明，相同的真皮组织细胞可能非选择性吞噬了铁血黄素和黑色素颗粒。

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