首页> 外文期刊>Archives of disease in childhood. Fetal and neonatal edition >Infant, obstetrical and maternal characteristics associated with thromboembolism in infancy: a nationwide population-based case-control study.
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Infant, obstetrical and maternal characteristics associated with thromboembolism in infancy: a nationwide population-based case-control study.

机译:与婴儿血栓栓塞相关的婴儿,产科和产妇特征:一项基于全国人群的病例对照研究。

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摘要

To identify infant, obstetrical and maternal characteristics associated with arterial ischaemic stroke (AIS) and venous thromboembolism (VTE) in infancy (<1 year).Nationwide, population-based nested case-control study. All infants with a verified first-time diagnosis of AIS, VTE or both in Denmark through the years 1994-2006 were included, and 10 population controls were selected for each case.Case-infants presented with AIS (n=71) or VTE (n=38). AIS in infancy was associated with primiparity (adjusted OR 5.9 CI 95% 3.0 to 11.6)), delivery by an emergency caesarean section (adjusted OR 1.9 (CI 95% 1.0 to 3.3)), and post-term birth (adjusted OR 2.2 (CI 95% 1.1 to 4.8)). Male sex was associated with an increased risk of AIS among neonates (crude OR 1.8 (CI 95% 1.0 to 3.4)) but not among later born (crude OR 0.6 (CI 95% 0.2 to 1.4)). Risk factors for VTE in infancy included preterm birth (adjusted OR 5.5 (CI 95% 1.8 to 16.9)), low Apgar score (adjusted OR 9.2 (CI 95% 1.9 to 45.2)), and multiple births (adjusted OR 7.1 (CI 95% 1.1 to 48.1)). Previous maternal thromboembolism and pregnancy-related disorders were not associated with the risk of thromboembolism in the children.Several apparently independent infant, obstetrical and maternal characteristics were associated with thromboembolism in early life.
机译:在婴儿期(<1年)中确定与婴儿缺血性卒中(AIS)和静脉血栓栓塞(VTE)相关的婴儿,产科和产妇特征。全国性,以人群为基础的嵌套病例对照研究。纳入了1994年至2006年间丹麦所有首次对AIS,VTE或两者同时进行首次诊断的婴儿,并为每例病例选择了10个人群对照。出现AIS(n = 71)或VTE的病例婴儿( n = 38)。婴儿期的AIS与初产有关(调整为OR 5.9 CI 95%3.0至11.6),紧急剖腹产(调整为OR 1.9(CI 95%1.0至3.3))和早产(调整OR 2.2( CI 95%1.1至4.8))。男性与新生儿AIS的风险增加相关(粗略的OR 1.8(CI 95%1.0至3.4)),而在较晚出生的人群中则不相关(粗略的OR 0.6(CI 95%0.2至1.4))。婴儿期VTE的危险因素包括早产(经调整OR 5.5(CI 95%1.8至16.9)),低Apgar分数(经调整OR OR 9.2(CI 95%1.9至45.2))和多胎(经OR调整为7.1(CI 95) %1.1至48.1))。以前的母亲血栓栓塞和与妊娠相关的疾病与儿童血栓栓塞的风险无关。早期婴儿中,一些明显独立的婴儿,产科和母亲特征与血栓栓塞有关。

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