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首页> 外文期刊>Archives of disease in childhood. Fetal and neonatal edition >A randomised, controlled trial of heparin in total parenteral nutrition to prevent sepsis associated with neonatal long lines: The Heparin in Long Line Total Parenteral Nutrition (HILLTOP) trial
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A randomised, controlled trial of heparin in total parenteral nutrition to prevent sepsis associated with neonatal long lines: The Heparin in Long Line Total Parenteral Nutrition (HILLTOP) trial

机译：肝素在全肠外营养中预防与新生儿延寿相关的败血症的随机对照试验：肝素在全肠外营养中的长期应用（HILLTOP）试验

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Background: Infections are common complications of neonatal long lines. Heparin has been shown to prolong the effective duration of neonatal long lines and to reduce the ability of bacteria to adhere to foreign surfaces, but the effect of heparin on rates of infection is uncertain. Objective: The goal of this study was to evaluate the effect of heparin on the frequency of episodes of catheter-related sepsis (CRS) in infants receiving total parenteral nutrition (TPN) through a neonatal long line. Design/Methods: This randomised, controlled, double blind, single-centre clinical trial compared heparin at 0.5 IU/ml with no heparin in TPN infused through a neonatal long line, with episodes of CRS as the primary outcome. Results: 210 infants were enrolled (TPN with heparin n=102, TPN without heparin n=108). There was a statistically significant reduction in all episodes of culture-positive CRS in those infants with heparin added to the TPN compared with those without heparin (p=0.04; RR 0.57, 95% CI 0.32 to 0.98; number needed to treat 9, 95% CI 4.6 to 212.4). Conclusions: The addition of heparin at 0.5 IU/ml to TPN infused through a neonatal long line reduces the incidence of culture-positive CRS.
机译：背景：感染是新生儿长线的常见并发症。肝素已被证明可以延长新生儿长系的有效持续时间，并降低细菌粘附异物表面的能力，但是肝素对感染率的影响尚不确定。目的：本研究的目的是通过新生儿长期研究评估肝素对接受全肠外营养（TPN）的婴儿的导管相关败血症（CRS）发作频率的影响。设计/方法：这项随机，对照，双盲，单中心的临床试验比较了通过新生儿长线输注的TPN中0.5 IU / ml肝素与不含肝素的TPN，以CRS发作为主要结果。结果：招募了210名婴儿（TPN肝素n = 102，TPN无肝素n = 108）。与未添加肝素的婴儿相比，在TPN中添加肝素的婴儿的所有文化阳性CRS发作均具有统计学显着性降低（p = 0.04; RR 0.57，95％CI 0.32至0.98;治疗9、95所需的数字％CI 4.6至212.4）。结论：在通过新生儿长线输注的TPN中添加0.5 IU / ml肝素可降低培养阳性CRS的发生率。

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