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首页> 外文期刊>Applied optics >Detection limit enhancement of fluorescent heterogeneities in turbid media by dual-interfering excitation
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Detection limit enhancement of fluorescent heterogeneities in turbid media by dual-interfering excitation

机译：双重干扰激发提高混浊介质中荧光异质性的检测限

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摘要

We report on a quantitative comparison between the single-source and the dual-interfering-source configurations for the detection of fluorescent heterogeneities embedded in a piecewise highly scattering homogeneous fluorescent background. The study is based on simulations with analytical solutions of the frequency-domain fluorescent diffuse photon density waves and practical signal-to-noise ratio considerations. Results show that dual-interfering sources outperform single-source techniques for the detection of heterogeneities in terms of fluorophore concentration and lifetime contrast. To detect the same inhomogeneity, less concentration and lifetime contrast is required with dual-interfering sources.
机译：我们报告了定量检测单源和双干扰源之间的定量比较，以检测嵌入在分段高度散射的均匀荧光背景中的荧光异质性。这项研究是基于对频域荧光扩散光子密度波的解析解和实际信噪比考虑的模拟。结果表明，就荧光团浓度和寿命对比而言，双干扰源优于异源检测的单源技术。为了检测相同的不均匀性，双干扰源需要的浓度和寿命对比要小一些。

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