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首页> 外文期刊>Applied optics >Concentration measurements of multiple analytes in human sera by near-infrared laser Raman spectroscopy
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Concentration measurements of multiple analytes in human sera by near-infrared laser Raman spectroscopy

机译：用近红外激光拉曼光谱法测量人体血清中多种分析物的浓度

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摘要

Our primary goal in this study is to demonstrate that near-infrared Raman spectroscopy is feasible as a rapid and reagentless analytic method for clinical diagnostics. Raman spectra were collected on human sera by use of a 785-nm excitation laser and a single-stage holographic spectrometer. A partial-leastsquares method was used to predict the analyte concentrations of interest. The prediction errors of total protein, albumin, triglyceride, and glucose in human sera ranged from 1.0% to 10%, which are highly acceptable for clinical diagnosis, of their mean physiological levels. For investigating the potential application of near-infrared Raman spectroscopy in screening of therapeutical drugs and substances of abuse the concentrations of acetaminophen, ethanol, and codeine in water solution were measured in the same fashion. The errors of thc Raman tests for acetaminophen and ethanol are lower than their toxic levels in human serum, and the sensitivity for detection of codeine fails to reach its toxic level.
机译：我们在这项研究中的主要目标是证明近红外拉曼光谱作为一种快速，无试剂的临床诊断分析方法是可行的。拉曼光谱是通过使用785 nm激发激光和单级全息光谱仪在人血清上收集的。使用偏最小二乘方法预测目标分析物的浓度。人血清中总蛋白，白蛋白，甘油三酸酯和葡萄糖的预测误差在其平均生理水平的1.0％至10％范围内，对于临床诊断是高度可接受的。为了研究近红外拉曼光谱在筛选治疗药物和滥用物质中的潜在应用，以相同方式测量了对乙酰氨基酚，乙醇和可待因在水溶液中的浓度。拉曼测试对乙酰氨基酚和乙醇的误差低于其在人血清中的毒性水平，可待因的检测灵敏度未达到其毒性水平。

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