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Can histologic parameters of melanoma metastases in sentinel lymph nodes reliably select patients who can be safely spared completion lymph node dissection?

机译:前哨淋巴结中黑色素瘤转移的组织学参数能否可靠地选择可以安全地完成淋巴结清扫术的患者?

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摘要

We read with interest the paper by Dr. van der Ploeg et al published in the August 2009 issue of Annals of Surgery. The authors compared 3 previously reported methods of characterizing histo-logic parameters of melanoma metastases in sentinel lymph nodes (SLNs). The goal was to determine which method was most predictive of additional lymph node involvement and survival, and to establish a SLN tumor burden threshold below which completion lymph node dissection (CLND) may be safely omitted. The overall SLN positivity rate of 26% is higher than that reported in many studies, and this relatively high rate of pick-up of metastases may be related to the pathologic protocol used in the examination of the SLNs. Studies have previously shown that the more extensively SLNs are examined pathologically, the higher the rate of pick-up of melanoma metastases.
机译:我们感兴趣地阅读了van der Ploeg博士等人发表于2009年8月的《外科医学年鉴》上的论文。作者比较了3种先前报道的表征前哨淋巴结(SLN)中黑色素瘤转移的组织学参数的方法。目的是确定最能预测其他淋巴结受累和生存的方法,并确定SLN肿瘤负荷阈值,在该阈值以下可以安全地省略淋巴结清扫术(CLND)。总的SLN阳性率为26%,高于许多研究报告的水平,转移灶的相对较高的转移率可能与SLN的检查所使用的病理学方案有关。先前的研究表明,病理检查SLN的范围越广,黑色素瘤转移的发生率越高。

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