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Heterodyne quasi-elastic light-scattering instrument for biomedical diagnostics

机译：用于生物医学诊断的外差准弹性光散射仪

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The heterodyne technique has a number of advantages over the homodyne technique when an accurate characterization of particle-size distribution (PSD) of heterogeneous systems is required. However, there are problems related to acoustic vibrations that make it difficult to take advantage of the heterodyne technique. An instrument developed for quasi-elastic light scattering (QELS) that uses the optical heterodyning principle is described. Vibration-related problems are considerably reduced because of the incorporation of all optical elements into one solid optical block. A real-time correlation analysis of the photocurrent fluctuations is performed by a PC-embedded analog-to-digital converter card with a digital signal processor. Investigation of the PSD in biological fluids for medical diagnostics is presented as a typical application. A diagnostic analysis of the PSD requires a simultaneous processing of a huge number of QELS data. An original statistical algorithm to accomplish this analysis has been developed. Technical specifications of instrumentation for heterodyne QELS measurement are discussed. (C) 1997 Optical Society of America.
机译：当需要对异质系统的粒度分布（PSD）进行精确表征时，外差技术比同差技术具有许多优势。然而，存在与声振动有关的问题，这使得难以利用外差技术。描述了一种使用光学外差原理为准弹性光散射（QELS）开发的仪器。由于将所有光学元件集成到一个固态光学模块中，大大减少了与振动相关的问题。光电流波动的实时相关性分析是通过带有数字信号处理器的PC嵌入式模数转换器卡进行的。典型应用是对生物流体中PSD的研究，以用于医学诊断。 PSD的诊断分析需要同时处理大量QELS数据。已经开发出完成该分析的原始统计算法。讨论了外差QELS测量仪器的技术规范。 （C）1997年美国眼镜学会。

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