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首页> 外文期刊>Annals of surgical oncology >Down-regulation of stromal caveolin-1 expression in esophageal squamous cell carcinoma: A potent predictor of lymph node metastases, early tumor recurrence, and poor prognosis
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Down-regulation of stromal caveolin-1 expression in esophageal squamous cell carcinoma: A potent predictor of lymph node metastases, early tumor recurrence, and poor prognosis

机译：食管鳞状细胞癌中基质小窝蛋白1表达的下调：淋巴结转移，早期肿瘤复发和预后不良的有效预测指标。

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Background: Recent studies have identified loss of stromal caveolin-1 (Cav-1) expression as a new prognostic histological characteristic in various types of human cancers. However, the clinical and pathological significance of stromal Cav-1 expression in esophageal squamous cell carcinoma (ESCC) remains largely unknown. We examined Cav-1 expression in both tumor and stromal cells in ESCC tissue by immunohistochemical analysis to evaluate its clinicopathological significance and prognostic value. Methods: A total of 110 patients with ESCC who underwent surgical resection were included in this study. The expression of Cav-1 in both tumor and stromal cells in esophageal tumor tissues was examined immunohistochemically. Results: Cav-1 expression was found in the cytoplasm of both tumor and stromal cells. Tumor Cav-1 overexpression was observed in 37.3 % tumors, which correlated to deeper tumor invasion (p = 0.038). Down-regulation of stromal Cav-1 expression was observed in 40.9 % tumors. The stromal Cav-1 down-regulation group had more lymph node metastases and more locoregional recurrences than those with higher expression (p = 0.020 and p = 0.002, respectively). In addition, down-regulation of stromal Cav-1 expression was associated with shorter disease-free survival (p < 0.001) and overall survival (p < 0.001). Multivariate analysis revealed that down-regulation of stromal Cav-1 expression was an independent prognostic factor for both disease-free survival (p = 0.028) and overall survival (p = 0.007). Conclusions: Down-regulation of stromal Cav-1 expression in ESCC had high malignant potential. It predicts high-risk of lymph node metastases and locoregional recurrence, and it could be a powerful prognostic marker for patients with ESCC.
机译：背景：最近的研究已确定基质小窝蛋白1（Cav-1）表达的丧失是各种类型的人类癌症中新的预后组织学特征。然而，食管鳞状细胞癌（ESCC）中基质Cav-1表达的临床和病理意义仍然未知。我们通过免疫组织化学分析了ESCC组织中肿瘤和基质细胞中Cav-1的表达，以评估其临床病理意义和预后价值。方法：本研究共纳入110例行手术切除的ESCC患者。免疫组织化学检查了Cav-1在食管肿瘤组织中的肿瘤和基质细胞中的表达。结果：在肿瘤和基质细胞的细胞质中均发现了Cav-1表达。在37.3％的肿瘤中观察到肿瘤Cav-1过表达，这与更深的肿瘤浸润相关（p = 0.038）。在40.9％的肿瘤中观察到基质Cav-1表达的下调。与高表达者相比，间质Cav-1下调组的淋巴结转移和局部复发率更高（分别为p = 0.020和p = 0.002）。此外，基质Cav-1表达的下调与较短的无病生存期（p <0.001）和总体生存期（p <0.001）相关。多变量分析显示，基质Cav-1表达的下调是无病生存期（p = 0.028）和总体生存期（p = 0.007）的独立预后因素。结论：ESCC中基质Cav-1表达的下调具有较高的恶性潜能。它预示着淋巴结转移和局部复发的高风险，它可能是ESCC患者的有力预后指标。

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